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Scholar Results 1 - 10 of about 33 citing Renström: Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+.... (0.07 sec) 

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B- …

- rupress.org
L Eliasson, X Ma, E Renstrom, S Barg, PO … - Journal of General Physiology, 2003 - jgp.rupress.org
Measurements of membrane capacitance were applied to dissect the cellular
mechanisms underlying PKA-dependent and -independent stimulation of insulin
secretion by cyclic AMP. Whereas the PKA-independent ...
Cited by 112 - Related articles - BL Direct - All 5 versions

Pharmacological agents that directly modulate insulin secretion

- aspetjournals.org
ME Doyle, JM Egan - Pharmacological reviews, 2003 - ASPET
Blood glucose levels are sensed and controlled by the release of hormones from
the islets of Langerhans in the pancreas. The -cell, the insulin-secreting cell
in the islet, can detect subtle increases in circulating glucose levels and ...
Cited by 79 - Related articles - BL Direct - All 8 versions

Glucose-sensing in glucagon-like peptide-1-secreting cells


F Reimann, FM Gribble - Diabetes, 2002 - Am Diabetes Assoc
Glucagon-like peptide-1 (GLP-1) is released from intestinal L-cells in response
to carbohydrate and fat in the diet. Despite the interest in GLP-1 as an
antidiabetic agent, very little is known about the mechanism of stimulus- ...
Cited by 71 - Related articles - BL Direct - All 5 versions

Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells


S Barg - Pharmacology and Toxicology, 2003 - interscience.wiley.com
Abstract: In pancreatic B- and A-cells, metabolic stimuli regulate biochemical
and electrical processes that culminate in Ca 2+ -influx and release of insulin
or glucagon, respectively. Like in other (neuro)endocrine cells, Ca 2+ ...
Cited by 49 - Related articles - BL Direct - All 7 versions

Gliclazide protects pancreatic β-cells from damage by hydrogen peroxide


K Kimoto, K Suzuki, T Kizaki, Y Hitomi, H … - Biochemical and Biophysical Research …, 2003 - Elsevier
Oxidative stress is induced under diabetic conditions and possibly causes
various forms of tissue damage in patients with diabetes. Recently, it has
become aware that susceptibility of pancreatic β-cells to oxidative stress ...
Cited by 46 - Related articles - All 4 versions

Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin …

- diabetesjournals.org
JC Henquin - Diabetes, 2004 - Am Diabetes Assoc
Physiologically, insulin secretion is subject to a dual, hierarchal control by
triggering and amplifying pathways. By closing ATP-sensitive K + channels (K ATP
channels) in the plasma membrane, glucose and other metabolized nutrients ...
Cited by 37 - Related articles - BL Direct - All 4 versions

Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC- …

- physiology.org
M Lehtihet, N Welsh, PO Berggren, GA Cook, … - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc
Hypoglycemic sulfonylureas such as glibenclamide have been widely used to treat
type 2 diabetic patients for 40 yr, but controversy remains about their mode of
action. The widely held view is that they promote rapid insulin exocytosis ...
Cited by 26 - Related articles - BL Direct - All 3 versions

Membrane ion channels and diabetes


P Proks, JD Lippiat - Current pharmaceutical design, 2006 - ingentaconnect.com
Abstract: Type-2, or non-insulin-dependent diabetes mellitus is a serious
disease that is now widespread throughout Western society. Glucose intolerance,
or failure of glucose to stimulate insulin secretion, is a primary factor ...
Cited by 19 - Related articles - BL Direct - All 4 versions

Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic …


C Spirlì, R Fiorotto, L Song, J Santos-Sacchi … - Gastroenterology, 2005 - Elsevier
Background & Aims: Progressive liver disease is a severe complication of cystic
fibrosis, a genetic disease characterized by impaired epithelial adenosine
3′,5′-cyclic monophosphate-dependent secretion caused by mutations in ...
Cited by 12 - Related articles - All 16 versions

Antidiabetic sulphonylureas activate mitochondrial permeability transition in rat skeletal …


J Skalska, G Debska, WS Kunz, A Szewczyk - British journal of pharmacology, 2005 - pubmedcentral.nih.gov
Antidiabetic sulphonylureas can bind to various intracellular organelles
including mitochondria. The aim of this study was to monitor the influence of
antidiabetic sulphonylureas on membrane permeability in mitochondria ...
Cited by 8 - Related articles - All 4 versions


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