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Scholar Results 1 - 10 of about 43 citing Wollheim: β-Cell Mitochondria and Insulin Secretion. (0.09 sec) 

The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion

- bcell.org [PDF] 
PE MacDonald, W El-kholy, MJ Riedel, AMF … - Diabetes, 2002 - Am Diabetes Assoc
The physiological effects of glucagon-like peptide-1 (GLP-1) are of immense
interest because of the potential clinical relevance of this peptide. Produced
in intestinal L-cells through posttranslational processing of the ...
Cited by 95 - Related articles - BL Direct - All 4 versions

[PDF] Glutamine and glutamate-their central role in cell metabolism and function


P Newsholme, J Procopio, MMR Lima, TC … - Cell biochemistry and function, 2003 - erin.utoronto.ca
Glucose is widely accepted as the primary nutrient for maintenance and promotion
of cell function. However, we propose that the 5-carbon amino acids, glutamine
and glutamate, should be considered to be equally important for maintenance ...
Cited by 84 - Related articles - View as HTML - BL Direct - All 5 versions

Amino acid transporters: roles in amino acid sensing and signalling in animal cells.


R Hyde, PM Taylor, HS Hundal - Biochemical Journal, 2003 - pubmedcentral.nih.gov
Amino acid availability regulates cellular physiology by modu- lating gene
expression and signal transduction pathways. How- ever, although the signalling
intermediates between nutrient availability and altered gene expression ...
Cited by 80 - Related articles - BL Direct - All 9 versions

Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in …

- physiology.org
MJ MacDonald, LA Fahien, LJ Brown, NM … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc
The importance of mitochondrial biosynthesis in stimulus secretion coupling in
the insulin-producing -cell probably equals that of ATP production. In
glucose-induced insulin secretion, the rate of pyruvate carboxylation is ...
Cited by 60 - Related articles - All 4 versions

The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival …

- rupress.org
T Brun, I Franklin, L St-Onge, A Biason- … - Journal of Cell Biology, 2004 - jcb.rupress.org
The mechanism by which the ß-cell transcription factor Pax4 influences cell
function/mass was studied in rat and human islets of Langerhans. Pax4
transcripts were detected in adult rat islets, and levels were induced by ...
Cited by 57 - Related articles - All 11 versions

Glutamine and glutamate as vital metabolites


P Newsholme, MMR Lima, J Procopio, TC … - Brazilian Journal of Medical and Biological Research, 2003 - SciELO Brasil
Glucose is widely accepted as the primary nutrient for the maintenance and
promotion of cell function. This metabolite leads to production of ATP, NADPH
and precursors for the synthesis of macromolecules such as nucleic acids ...
Cited by 57 - Related articles - Cached - BL Direct - All 12 versions

A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J …

- pubget.com [PDF] 
AA Toye, JD Lippiat, P Proks, K Shimomura, L … - Diabetologia, 2005 - Springer
Page 1. Diabetologia (2005) 48: 675–686 DOI 10.1007/s00125-005-1680-z ARTICLE AA
Toye . JD Lippiat . P. Proks . K. Shimomura . L.Bentley . A. Hugill . ...
Cited by 55 - Related articles - All 4 versions

Minireview: implication of mitochondria in insulin secretion and action

- endojournals.org
A Wiederkehr, CB Wollheim - Endocrinology, 2006 - Endocrine Soc
Mitochondria are essential for intermediary metabolism as well as energy
production in the cell. Their aerobic metabolism permits oxidation of glucose
and fatty acids for the generation of ATP and other intermediates that are ...
Cited by 53 - Related articles - BL Direct - All 4 versions

Synaptotagmin V and IX isoforms control Ca2+-dependent insulin exocytosis

- biologists.org
M Iezzi, G Kouri, M Fukuda, CB Wollheim - Journal of cell science, 2004 - jcs.biologists.org
Synaptotagmin (Syt) is involved in Ca 2+ -regulated secretion and has been
suggested to serve as a general Ca 2+ sensor on the membrane of secretory
vesicles in neuronal cells. Insulin exocytosis from the pancreatic ß-cell ...
Cited by 52 - Related articles - BL Direct - All 5 versions

Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 …


M Anello, R Lupi, D Spampinato, S Piro, M … - Diabetologia, 2005 - Springer
Abstract Aims/hypothesis: Little information is available on the insulin release
properties of pancreatic islets iso- lated from type 2 diabetic subjects. Since
mitochondria represent the site where important metabolites that regulate ...
Cited by 42 - Related articles - All 3 versions


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