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Scholar Results 1 - 10 of about 22 citing Roper: Effect of the insulin mimetic L-783,281 on intracellular [Ca2+] and insulin secretion.... (0.22 sec) 

The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks Kv currents via a …

- fasebj.org [PDF] 
W El-kholy, PE MacDonald, JH Lin, J Wang, … - The FASEB Journal, 2003 - FASEB
Page 1. The FASEB Journal express article 10.1096/fj.02-0802fje. Published online
February 5, 2003. The phosphatidylinositol 3-kinase inhibitor LY294002 ...
Cited by 44 - Related articles - BL Direct - All 5 versions

The Role of Voltage-Gated Calcium Channels in Pancreatic {beta}-Cell Physiology and …

- endojournals.org
SN Yang, PO Berggren - Endocrine reviews, 2006 - Endocrine Soc
Voltage-gated calcium (Ca V ) channels are ubiquitously expressed in various
cell types throughout the body. In principle, the molecular identity,
biophysical profile, and pharmacological property of Ca V channels are ...
Cited by 34 - Related articles - BL Direct - All 6 versions

{beta}-Cell CaV channel regulation in physiology and pathophysiology

- physiology.org
SN Yang, PO Berggren - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc
The -cell is equipped with at least six voltage-gated Ca 2+ (Ca V ) channel 1
-subunits designated Ca V 1.2, Ca V 1.3, Ca V 2.1, Ca V 2.2, Ca V 2.3, and Ca V
3.1. These principal subunits, together with certain auxiliary subunits, ...
Cited by 31 - Related articles - All 3 versions

Insulin constitutively secreted by β-cells is necessary for glucose-stimulated insulin secretion

- diabetesjournals.org
S Srivastava, HJ Goren - Diabetes, 2003 - Am Diabetes Assoc
Four hypotheses have been posited on the role of insulin in glucose-stimulated
insulin secretion; available evidence has supported insulin as being 1)
essential, 2) a positive modulator, 3) a negative modulator, or 4) not ...
Cited by 19 - Related articles - BL Direct - All 4 versions

Insulin feedback alters mitochondrial activity through an ATP-sensitive K+ channel– …


CS Nunemaker, M Zhang, LS Satin - Diabetes, 2004 - Am Diabetes Assoc
Recent work suggests that insulin may exert both positive and negative feedback
directly on pancreatic β-cells. To investigate the hypothesis that insulin
modulates β-cell metabolism, mouse islets and β-cell clusters were loaded ...
Cited by 15 - Related articles - BL Direct - All 5 versions

Small-molecule insulin mimetic reduces hyperglycemia and obesity in a nongenetic mouse …

- endojournals.org
MZ Strowski, Z Li, D Szalkowski, X Shen, XM … - Endocrinology, 2004 - Endocrine Soc
Adiposity positively correlates with insulin resistance and is a major risk
factor of type 2 diabetes. Administration of exogenous insulin, which acts as an
anabolic factor, facilitates adipogenesis. Recently nonpeptidal insulin ...
Cited by 12 - Related articles - BL Direct - All 4 versions

Insulin receptor signaling and sarco/endoplasmic reticulum calcium ATPase in β-cells


PD Borge, J Moibi, SR Greene, M Trucco, RA … - Diabetes, 2002 - Am Diabetes Assoc
Glucose is the main physiological secretagogue for insulin secretion by
pancreatic β-cells, and the major biochemical mechanisms involved have been
elucidated. In particular, an increase in intracellular calcium is ...
Cited by 11 - Related articles - BL Direct - All 3 versions

Long-term inhibition of protein tyrosine kinase impairs electrophysiologic activity and a …

- endocrinology-journals.org
YF Zhao, DJ Keating, M Hernandez, DD Feng, … - Journal of molecular endocrinology, 2005 - Soc Endocrinology
Dysfunction of pancreatic ß-cells is a fundamental feature in the pathogenesis
of type 2 diabetes. As insulin receptor signaling occurs via protein tyrosine
kinase (PTK), we investigated the role of PTK activity in the etiology of ...
Cited by 7 - Related articles - BL Direct - All 4 versions

Therapeutic Actions of an Insulin Receptor Activator and a Novel Peroxisome Proliferator …

- aspetjournals.org
RA Velliquette, JE Friedman, J Shao, BB … - Journal of Pharmacology and Experimental …, 2005 - ASPET
Insulin resistance clusters with hyperlipidemia, impaired glucose tolerance, and
hypertension as metabolic syndrome X. We tested a low molecular weight insulin
receptor activator, demethylasterriquinone B-1 (DMAQ-B1), and a novel ...
Cited by 7 - Related articles - BL Direct - All 5 versions

Hinnuliquinone, a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 …


SB Singh, JG Ondeyka, N Tsipouras, C Ruby, … - Biochemical and Biophysical Research …, 2004 - Elsevier
HIV-1 protease is one of several key enzymes required for the replication and
maturation of HIV-1 virus. An almost two-decade research effort by academic and
pharmaceutical institutions resulted in the successful commercialization of ...
Cited by 3 - Related articles - All 4 versions


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