P Rorsman, E Renström - Diabetologia, 2003 - Springer Glucose-induced insulin secretion in response to a step increase in blood
glucose concentrations follows a bi- phasic time course consisting of a rapid
and transient first phase followed by a slowly developing and sus- tained ... Cited by 205 - Related articles - BL Direct - All 3 versions
SG Straub, GWG Sharp - Diabetes/Metabolism Reviews - interscience.wiley.com Glucose-stimulated biphasic insulin secretion involves at least two signaling
pathways, the KATP channel-dependent and KATP channel-independent pathways,
respectively. In the former, enhanced glucose metabolism increases the ... Cited by 156 - Related articles - BL Direct - All 3 versions
- ►physiology.org S Seino, T Shibasaki - Physiological reviews, 2005 - Am Physiological Soc Stimulus-secretion coupling is an essential process in secretory cells in which
regulated exocytosis occurs, including neuronal, neuroendocrine, endocrine, and
exocrine cells. While an increase in intracellular Ca 2+ concentration ([Ca ... Cited by 145 - Related articles - BL Direct - All 4 versions
- ►physiology.org MJ Dunne, KE Cosgrove, RM Shepherd, A … - Physiological reviews, 2004 - Am Physiological Soc The earliest description of hyperinsulinism appears to have been that provided
by Laidlaw in 1938 who used the term nesidioblastosis to describe the severe,
recurrent hypoglycemia associated with an inappropriate elevation of serum ... Cited by 108 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org R Roduit, C Nolan, C Alarcon, P Moore, A … - Diabetes, 2004 - Am Diabetes Assoc The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin
secretion (GIIS) predicts that malonyl-CoA derived from glucose metabolism
inhibits fatty acid oxidation, thereby increasing the availability of ... Cited by 88 - Related articles - BL Direct - All 7 versions
E Ferrannini, A Mari - Diabetologia, 2004 - Springer The importance of both insulin resistance and beta cell dysfunction in the
pathogenesis of glucose intolerance is widely recognised. Also popular is the
concept that beta cell secretory function must be viewed in the context of ... Cited by 76 - Related articles - BL Direct - All 4 versions
- ►nih.gov RK Gupta, MZ Vatamaniuk, CS Lee, RC … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in
maturity-onset diabetes of the young (MODY). To determine the contribution of
HNF-4α to the maintenance of glucose homeostasis by the β cell in vivo, ... Cited by 75 - Related articles - All 7 versions
V Schulla, E Renström, R Feil, S Feil, I … - The EMBO Journal, 2003 - pubmedcentral.nih.gov Insulin is secreted from pancreatic β cells in response to an elevation of
cytoplasmic Ca 2+ resulting from enhanced Ca 2+ influx through voltage-gated Ca
2+ channels. Mouse β cells express several types of Ca 2+ channel (L-, R- ... Cited by 75 - Related articles - All 3 versions
F Reimann, FM Gribble - Diabetes, 2002 - Am Diabetes Assoc Glucagon-like peptide-1 (GLP-1) is released from intestinal L-cells in response
to carbohydrate and fat in the diet. Despite the interest in GLP-1 as an
antidiabetic agent, very little is known about the mechanism of stimulus- ... Cited by 71 - Related articles - BL Direct - All 5 versions
- ►molbiolcell.org A Varadi, T Tsuboi, GA Rutter - Molecular biology of the cell, 2005 - Am Soc Cell Biol The role of unconventional myosins in neuroendocrine cells is not fully
understood, with involvement suggested in the movement of both secretory
vesicles and mitochondria. Here, we demonstrate colocalization of myosin Va ... Cited by 63 - Related articles - All 6 versions
