- ►diabetesjournals.org R Roduit, C Nolan, C Alarcon, P Moore, A Barbeau, V … - Diabetes, 2004 - Am Diabetes Assoc The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin secretion (GIIS)
predicts that malonyl-CoA derived from glucose metabolism inhibits fatty acid oxidation, thereby
increasing the availability of ... Cited by 89 - Related articles - BL Direct - All 7 versions
- ►bcell.org [PDF] PE MacDonald, MB Wheeler - Diabetologia, 2003 - Springer Insulin secretion from pancreatic islet beta cells is acutely regulated by a complex interplay of
metabolic and electrogenic events. The electrogenic mechanism regulating insulin secretion from beta
cells is com- monly referred to as ... Cited by 74 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JC Henquin - Diabetes, 2004 - Am Diabetes Assoc Physiologically, insulin secretion is subject to a dual, hierarchal control by triggering and
amplifying pathways. By closing ATP-sensitive K + channels (K ATP channels) in the plasma membrane,
glucose and other metabolized ... Cited by 37 - Related articles - BL Direct - All 4 versions
Y Li, R Zhang, H Qiao, H Zhang, Y Wang, … - Journal of cellular …, 2007 - interscience.wiley.com Islet cell replacement is considered as the optimal treatment for type I diabetes. However, the
availability of human pancreatic islets for transplantation is limited. Here, we show that human
bone marrow-derived mesenchymal ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►physiology.org … , OP McGuinness, IR Sweet, JC Teague, … - American Journal of …, 2006 - Am Physiological Soc Islets in most species respond to increased glucose with biphasic insulin secretion, marked by a
sharp first-phase peak and a slowly rising second phase. Mouse islets in vitro, however, lack a
robust second phase. To date, this ... Cited by 14 - Related articles - BL Direct - All 4 versions
H Zhang, M Nagasawa, S Yamada, H … - The Journal of …, 2004 - Physiological Soc The present study was conducted to evaluate the role of conventional protein kinase C (PKC) in
calcium-evoked insulin secretion. In rat β cells transfected with green fluorescent protein-tagged
PKC-α (PKC-α–EGFP), a ... Cited by 13 - Related articles - All 7 versions
- ►physiology.org NM Doliba, W Qin, MZ Vatamaniuk, CW … - American Journal of …, 2006 - Am Physiological Soc Neural and endocrine factors (ie, Ach and GLP-1) restore defective glucose-stimulated insulin
release in pancreatic islets lacking sulfonylurea type 1 receptors (SUR1 –/– ) (Doliba NM, Qin
W, Vatamaniuk MZ, Li C, Zelent D, ... Cited by 12 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] T Aizawa, M Komatsu - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig In pancreatic β cells, not only insulin exocytosis per se, but translocation of β granules toward
the plasma membrane — an event upstream of exocytosis — are under the control of glucose.
However, the molecular basis of ... Cited by 12 - Related articles - All 6 versions
- ►googlepages.com [PDF] Y Guiot, M Stevens, I Marhfour, P Stiernet, M Mikhailov, … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Sulfonylurea receptor 1 (SUR1) is the regulatory subunit of ATP-sensitive K
channels in beta cells. Morphological methods (immunohistochemistry and sulfonylurea binding) were
used to establish the cellular and ... Cited by 4 - Related articles - BL Direct - All 5 versions
