- ►nih.gov F Preitner, M Ibberson, I Franklin, C Binnert, … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig The role of the gluco-incretin hormones GIP and GLP-1 in the control of β cell
function was studied by analyzing mice with inactivation of each of these
hormone receptor genes, or both. Our results demonstrate that glucose ... Cited by 95 - Related articles - BL Direct - All 10 versions
V Schulla, E Renström, R Feil, S Feil, I … - The EMBO Journal, 2003 - pubmedcentral.nih.gov Insulin is secreted from pancreatic β cells in response to an elevation of
cytoplasmic Ca 2+ resulting from enhanced Ca 2+ influx through voltage-gated Ca
2+ channels. Mouse β cells express several types of Ca 2+ channel (L-, R- ... Cited by 75 - Related articles - All 3 versions
- ►diabetesjournals.org CB Wollheim, P Maechler - Diabetes, 2002 - Am Diabetes Assoc The β-cell mitochondria are known to generate metabolic coupling factors, or
messengers, that mediate plasma membrane depolarization and the increase in
cytosolic Ca 2+ , the triggering event in glucose-stimulated insulin ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►shouxi.net JC Henquin, M Nenquin, P Stiernet, B Ahren - Diabetes, 2006 - Am Diabetes Assoc The mechanisms underlying biphasic insulin secretion have not been completely
elucidated. We compared the pattern of plasma insulin changes during
hyperglycemic clamps in mice to that of glucose-induced insulin secretion ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►unige.ch [PDF] P Maechler, S Carobbio, B Rubi - International Journal of Biochemistry and Cell Biology, 2006 - Elsevier Pancreatic beta-cells are unique neuroendocrine cells displaying the peculiar
feature of responding to nutrients, principally glucose, as primary stimulus.
This requires translation of a metabolic substrate into intracellular ... Cited by 29 - Related articles - All 7 versions
N Produit-Zengaffinen, N Davis-Lameloise, H … - Diabetologia, 2007 - Springer Page 1. ARTICLE Increasing uncoupling protein-2 in pancreatic beta cells does
not alter glucose-induced insulin secretion but decreases ... Cited by 26 - Related articles - BL Direct - All 4 versions
C Kampf, T Lau, R Olsson, PS Leung, PO … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: We recently found evidence of an
angiotensin-generating system in pancreatic islets. The present study
investigated the effect of endogenously pro- duced angiotensin II on ... Cited by 26 - Related articles - All 5 versions
- ►diabetesjournals.org A Kelly, C Li, Z Gao, CA Stanley, FM … - Diabetes, 2002 - Am Diabetes Assoc Identification of regulatory mutations of glutamate dehydrogenase (GDH) in a
form of congenital hyperinsulinism (GDH-HI) is providing a model for basal
insulin secretion (IS) and amino acid (AA)-stimulated insulin secretion ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►pnas.org DM Schumann, K Maedler, I Franklin, D Konrad … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Pancreatic β cell mass and function increase in conditions of enhanced insulin
demand such as obesity. Failure to adapt leads to diabetes. The molecular
mechanisms controlling this adaptive process are unclear. Fas is a death ... Cited by 20 - Related articles - BL Direct - All 11 versions
- ►physiology.org K Eto, T Yamashita, K Hirose, Y Tsubamoto, … - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc We studied acute changes of secretory vesicle pH in pancreatic -cells with a
fluorescent pH indicator, lysosensor green DND-189. Fluorescence was decreased
by 0.66 ± 0.10% at 149 ± 16 s with 22.2 mM glucose stimulation, ... Cited by 16 - Related articles - BL Direct - All 4 versions
