E Bugianesi, AJ McCullough, G Marchesini… - Hepatology, 2005 - interscience.wiley.com Insulin resistance (IR) is the pathophysiological hallmark of nonalcoholic fatty
liver disease (NAFLD), one of the most common causes of chronic liver disease in
Western countries. We review the definition of IR, the methods for the ... Cited by 169 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org AS Karban, T Okazaki, CIM Panhuysen, T … - Human molecular genetics, 2004 - Oxford Univ Press Nuclear Factor- B (NF- B) is a major transcription regulator of immune response,
apoptosis and cell-growth control genes, and is upregulated in inflammatory
bowel disease (IBD), both ulcerative colitis (UC) and Crohn's disease. The ... Cited by 104 - Related articles - BL Direct - All 5 versions
S Onengut-Gumuscu, KG Ewens, RS … - Genes and immunity, 2004 - nature.com Type I diabetes (T1D) is a complex disorder, which arises from the autoimmune
destruction of the insulin-secreting cells of the pancreas leading to a
life-long dependence on exogenous insulin. A recent study of T1D cases and ... Cited by 69 - Related articles - All 2 versions
- ►harvard.edu [PDF] CE Larsen, CA Alper - Current opinion in immunology, 2004 - Elsevier Type 1 diabetes mellitus (T1D) remains the most intensively studied, and thus
the best paradigm, of MHC-associated diseases. Accumulating evidence suggests
that MHC susceptibility for T1D is recessive, with susceptibility alleles ... Cited by 60 - Related articles - All 4 versions
R Gianani, GS Eisenbarth - Immunological reviews, 2005 - interscience.wiley.com Summary: Type 1A diabetes is a chronic autoimmune disease usually preceded by a
long prodrome during which autoantibodies to islet autoantigens are present.
These antibodies are directed to a variety of antigens, but the best ... Cited by 42 - Related articles - All 4 versions
- ►shouxi.net S Onengut-Gumuscu, JH Buckner, P … - Diabetes, 2006 - Am Diabetes Assoc A recent addition to the list of widely confirmed type 1 diabetes risk loci is
the PTPN22 gene encoding a lymphoid-specific phosphatase (Lyp). However,
evidence supporting a role for PTPN22 in type 1 diabetes derives entirely ... Cited by 28 - Related articles - BL Direct - All 6 versions
- ►nih.gov FA Kondrashov, AY Ogurtsov, AS Kondrashov - Nucleic acids research, 2004 - Oxford Univ Press Only a fraction of eukaryotic genes affect the phenotype drastically. We
compared 18 parameters in 1273 human morbid genes, known to cause diseases, and
in the remaining 16 580 unambiguous human genes. Morbid genes evolve more ... Cited by 25 - Related articles - BL Direct - All 11 versions
G Marchesini, G Forlani, E Bugianesi - Annals of Medicine, 2005 - informahealthcare.com The association of metabolic disorders with liver disease is receiving
increasing attention in the gastroenterological community. Cohort studies have
shown that advanced liver disease may stem from metabolic disorders, via ... Cited by 20 - Related articles - BL Direct - All 7 versions
HW Haverkos, N Battula, DP Drotman, OM … - Biomedicine & Pharmacotherapy, 2003 - Elsevier Type 1 diabetes mellitus (DM) is the most common life-threatening endocrine
disorder of children and young adults worldwide and its incidence appears to be
increasing. Prevention of type 1 DM continues to challenge public health ... Cited by 18 - Related articles - All 4 versions
WA HAGOPIAN, AKE Lernmark, MJ REWERS, … - Annals of the New York Academy of Sciences, 2006 - cat.inist.fr The aim of the TEDDY study is to identify infectious agents, dietary factors, or
other environmental agents, including psychosocial factors, which may either
trigger islet autoimmunity, type 1 diabetes mellitus(T 1 DM), or both. The ... Cited by 16 - Related articles - BL Direct - All 3 versions
