JM Servitja, J Ferrer - Diabetologia, 2004 - Springer Transcription factors provide the genetic instructions that drive pancreatic
development and enable mature beta cells to function properly. To understand
fully how this is accomplished, it is necessary to unravel the regulatory ... Cited by 106 - Related articles - BL Direct - All 4 versions
- ►annals.org [PDF] GE Umpierrez, D Smiley, AE Kitabchi - Annals of internal medicine, 2006 - Am Coll Physicians Several investigators have reported that more than half of African- American
persons with new diagnoses of diabetic ketoacidosis have clinical, metabolic,
and immunologic features of type 2 diabetes during follow-up. These ... Cited by 57 - Related articles - BL Direct - All 6 versions
- ►nih.gov D Ma, JPH Shield, W Dean, I Leclerc, C Knauf, … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Transient neonatal diabetes mellitus (TNDM) is a rare inherited diabetic
syndrome apparent in the first weeks of life and again during early adulthood.
The relative contributions of reduced islet β cell number and impaired β ... Cited by 58 - Related articles - BL Direct - All 10 versions
D Melloul - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2004 - interscience.wiley.com Abstract: Differentiation of early foregut endoderm into pancreatic endocrine
and exocrine cells depends on a cascade of gene activation events controlled by
various transcription factors. The first molecular marker identified that ... Cited by 42 - Related articles - BL Direct - All 4 versions
S Ashizawa, FC Brunicardi, XP Wang - Pancreas, 2004 - journals.lww.com Many transcription factors are critical for ensuring proper embryonic
development of the endocrine pancreas and normal islet function. The
transcription factor pancreatic duodenal homeobox 1 (PDX-1) is uniformly ... Cited by 38 - Related articles - BL Direct - All 2 versions
- ►endocrinology-journals.org AM Ackermann, M Gannon - Journal of molecular endocrinology, 2007 - Soc Endocrinology Pancreatic ß-cells are responsible for producing all of the insulin required by
an organism to maintain glucose homeostasis. Defects in development,
maintenance, or expansion of ß-cell mass can result in impaired glucose ... Cited by 35 - Related articles - All 4 versions
- ►ukpmc.ac.uk Y Fujitani, S Fujitani, DF Boyer, M Gannon, … - Genes & development, 2006 - genesdev.cshlp.org Pdx1 (IPF-1 in humans, which is altered in MODY-4) is essential for pancreas
development and mature β-cell function. Pdx1 is expressed dynamically within
the developing foregut, but how its expression characteristics are linked ... Cited by 37 - Related articles - BL Direct - All 12 versions
AM Håkelien, KG Gaustad, P Collas - Biochemical and biophysical research communications, 2004 - Elsevier We report a transient modulation of cell fate in fibroblasts briefly exposed to
an extract derived from the rat insulin-producing β cell line, INS-1E. Primary
fetal rat fibroblasts were reversibly permeabilized with Streptolysin O, ... Cited by 25 - Related articles - All 4 versions
IS Schroeder, A Rolletschek, P Blyszczuk, G … - Nature Protocols, 2006 - nature.com Here, we describe a basic protocol for the in vitro differentiation of mouse
embryonic stem (ES) cells into insulin-producing cells. The three-step protocol
comprises (i) the formation of embryoid bodies, (ii) the spontaneous ... Cited by 20 - Related articles - BL Direct - All 3 versions
MA Karim, X Wang, TC Hale, SC Elbein - BMC Medical Genetics, 2005 - biomedcentral.com We identified 8 variants in the two populations, including a 3 bp insertion in
exon 2 (InsCCG243) in African Americans that resulted in an in-frame proline
insertion in the transactivation domain. No variant was associated with ... Cited by 12 - Related articles - Cached - All 8 versions
