S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes:
one would generate -cells ex vivo that are suitable for transplantation, and the
second would stimulate regeneration of -cells in the pancreas. Studies of ... Cited by 172 - Related articles - All 3 versions
- ►endojournals.org C Marshall, GA Hitman, CJ Partridge, A Clark … - Molecular Endocrinology, 2005 - Endocrine Soc Calpain-10 (CAPN10) is the first type 2 diabetes susceptibility gene to be
identified through a genome scan, with polymorphisms being associated with
altered CAPN10 expression. Functional data have been hitherto elusive, but ... Cited by 49 - Related articles - All 5 versions
JA Maassen, GMC Janssen, LM 't Hart - Annals of Medicine, 2005 - informahealthcare.com Abstract Mitochondria provide cells with most of the energy in the form of
adenosine triphosphate (ATP). Mitochondria are complex organelles encoded both
by nuclear and mtDNA. Only a few mitochondrial components are encoded by ... Cited by 38 - Related articles - All 6 versions
- ►diabetesjournals.org MC Sugden, MJ Holness - Diabetes, 2004 - Am Diabetes Assoc In this review, we discuss the influence of peroxisome proliferator-activated
receptor (PPAR)-α on islet insulin secretion and develop the hypothesis that
modulation of PPAR-α function may be important for the regulation of ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►physiology.org MZ Khaldi, Y Guiot, P Gilon, JC Henquin, JC … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Chronic hyperglycemia has been shown to induce either a lack of response or an
increased sensitivity to glucose in pancreatic -cells. We reinvestigated this
controversial issue in a single experimental model by culturing rat islets ... Cited by 29 - Related articles - BL Direct - All 5 versions
SA Hinke, K Hellemans, FC Schuit - The Journal of physiology, 2004 - Physiological Soc It is well established that the acute rise in plasma glucose and in the incretin
hormones glucose-dependent insulinotropic peptide (GIP) and glucagon-like
peptide-1 (7–36) amide (GLP-1), as occurs during a meal, is of pivotal ... Cited by 25 - Related articles - All 9 versions
- ►endojournals.org A Maffei, Z Liu, P Witkowski, F Moschella, GD … - Endocrinology, 2004 - Endocrine Soc The purpose of our study was to identify transcripts specific for
tissue-restricted, membrane-associated proteins in human islets that, in turn,
might serve as markers of healthy or diseased islet cell masses. Using ... Cited by 23 - Related articles - BL Direct - All 5 versions
F Diraison, E Motakis, LE Parton, GP Nason, I … - Diabetes, 2004 - Am Diabetes Assoc Accumulation of triglyceride in islets may contribute to the loss of
glucose-stimulated insulin secretion (GSIS) in some forms of type 2 diabetes
(Diraison et al., Biochem J 373:769–778, 2004). Here, we use adenoviral ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►biologists.org F Allagnat, D Martin, DF Condorelli, G Waeber … - Journal of cell science, 2005 - jcs.biologists.org The gap-junction protein connexin36 (Cx36) contributes to control the functions
of insulin-producing cells. In this study, we investigated whether the
expression of Cx36 is regulated by glucose in insulin-producing cells. ... Cited by 21 - Related articles - BL Direct - All 7 versions
- ►jbc.org J Buteau, A Shlien, S Foisy, D Accili - Journal of Biological Chemistry, 2007 - ASBMB Diabetes is associated with decreased pancreatic -cell function and mass. It is
unclear whether diabetes treatment should aim at restoring -cell
performance/mass or at inducing " -cell rest" to prevent further ... Cited by 20 - Related articles - All 6 versions
