- ►oxfordjournals.org F Ashcroft, P Rorsman - Human molecular genetics, 2004 - Oxford Univ Press Type 2 diabetes mellitus is a serious metabolic disease that afflicts around 5%
of the population in Western societies and over 150 million people worldwide. It
is characterized by elevation of the blood glucose concentration, usually ... Cited by 70 - Related articles - All 5 versions
- ►nih.gov [PDF] GDS Xavier, Q Qian, PJ Cullen, GA Rutter - Biochemical Journal, 2004 - pubmedcentral.nih.gov The importance of the insulin receptor (IR) and the insulin-like growth factor-1
receptor (IGF-1R) for glucose-regulated insulin secretion and gene expression in
pancreatic islet β-cells is at present unresolved. Here, we have used ... Cited by 50 - Related articles - BL Direct - All 9 versions
H Wang, M Iezzi, S Theander, PA Antinozzi, … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Mutations in genes encoding HNF-4α, HNF-1α and
IPF-1/Pdx-1 are associated with, re- spectively, MODY subtypes-1, -3 and -4.
Impaired glucose- stimulated insulin secretion is the common primary defect ... Cited by 29 - Related articles - All 3 versions
FM Ashcroft, P Rorsman - Reviews in Endocrine & Metabolic Disorders, 2004 - Springer Key Words. pancreatic β-cells, insulin, KATP channel, MODY, diabetes ...
Type-2 diabetes is a multifactorial polygenic disease, char- acterised by
elevated blood glucose levels, that usually presents in middle age and is ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►endocrinology-journals.org KE Garnett, P Chapman, JA Chambers, ID … - Journal of molecular endocrinology, 2005 - Soc Endocrinology The ß-cell failure that characterises type 2 diabetes is likely to involve
altered expression of many genes. We aimed to identify global changes in gene
expression underlying ß-cell dysfunction in pre-diabetic Zucker Diabetic ... Cited by 21 - Related articles - BL Direct - All 5 versions
P Proks, JD Lippiat - Current pharmaceutical design, 2006 - ingentaconnect.com Abstract: Type-2, or non-insulin-dependent diabetes mellitus is a serious
disease that is now widespread throughout Western society. Glucose intolerance,
or failure of glucose to stimulate insulin secretion, is a primary factor ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►nih.gov H Wang, T Brun, K Kataoka, AJ Sharma, CB … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Effects of the transcription factor v-maf
musculoaponeurotic fibrosarcoma oncogene homologue A (MAFA) on the regulation of
beta cell gene expression and function were investigated. Materials and ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►nih.gov J Eeckhoute, P Formstecher, B Laine - Nucleic acids research, 2004 - Oxford Univ Press Hepatocyte Nuclear Factor 1 (HNF1 ) and Hepatocyte Nuclear Factor 4 (HNF4 ) are
two liver-enriched transcription factors coexpressed in specific tissues where
they play a crucial role through their involvement in a complex ... Cited by 19 - Related articles - BL Direct - All 10 versions
P Zhang, C Liu, C Zhang, Y Zhang, P Shen, J … - FEBS letters, 2005 - Elsevier PGC-1α mRNA and protein are elevated in islets from multiple animal models of
diabetes. Overexpression of PGC-1α impairs glucose-stimulated insulin secretion
(GSIS). However, it is not well known which metabolic events lead to ... Cited by 17 - Related articles - All 6 versions
