LD Stein, Z Bao, D Blasiar, T Blumenthal, MR Brent, … - PLoS Biol, 2003 - biology.plosjournals.org The soil nematodes Caenorhabditis briggsae and Caenorhabditis elegans diverged from a common
ancestor roughly 100 million years ago and yet are almost indistinguishable by eye. They have
the same chromosome number and genome sizes, and they occupy the same ecological ... Cited by 431 - Related articles - Cached - All 40 versions
I Barroso, RPS Jian'an Luan, AHH Middelberg, PW … - PLoS …, 2003 - pubmedcentral.nih.gov Type 2 diabetes is an increasingly common, serious metabolic disorder with a substantial inherited
component. It is characterised by defects in both insulin secretion and action. Progress in identification
of specific genetic variants predisposing to the disease has been limited. To complement ... Cited by 166 - Related articles - All 5 versions
I Barroso - Diabetic medicine, 2005 - interscience.wiley.com Type 2 diabetes (T2D) has become a health-care problem worldwide, with the rise in disease
prevalence being all the more worrying as it not only affects the developed world but also developing
nations with fewer resources to cope with yet another major disease burden. Furthermore, ... Cited by 101 - Related articles - All 6 versions
- ►oxfordjournals.org F Ashcroft, P Rorsman - Human molecular genetics, 2004 - Oxford Univ Press Type 2 diabetes mellitus is a serious metabolic disease that afflicts around 5% of the population
in Western societies and over 150 million people worldwide. It is characterized by elevation of
the blood glucose concentration, usually presents in middle age, and is exacerbated by ... Cited by 70 - Related articles - All 5 versions
- ►nih.gov SA Schäfer, O Tschritter, F Machicao, C Thamer, N … - Diabetologia, 2007 - Springer Page 1. ARTICLE Impaired glucagon-like peptide-1-induced insulin secretion in carriers of
transcription factor 7-like 2 (TCF7L2) gene polymorphisms SA Schäfer & O. Tschritter & F.
Machicao & C. Thamer & N. Stefan & B. Gallwitz & JJ Holst & JM Dekker & ... Cited by 57 - Related articles - BL Direct - All 9 versions
- ►hivinfosource.org [PDF] MJ Riedel, P Boora, D Steckley, G de Vries, PE Light - Diabetes, 2003 - Am Diabetes Assoc The commonly occurring E23K and I337V Kir6.2 polymorphisms in the ATP-sensitive potassium
(K ATP ) channel are more frequent in Caucasian type 2 diabetic populations. However, the underlying
cellular mechanisms contributing to the pathogenesis of type 2 diabetes remain ... Cited by 51 - Related articles - BL Direct - All 25 versions
- ►oxfordjournals.org H Freeman, RD Cox - Human molecular genetics, 2006 - Oxford Univ Press Diabetes is one of the most challenging health problems of the 21st century with an alarming
increase in the prevalence of type-2 diabetes mellitus (T2DM) and associated conditions such
as hypertension, dyslipidemias and obesity. T2DM is a complex genetic disease ... Cited by 48 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org JC Koster, MA Permutt, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The ATP-sensitive K + channel (K ATP channel) senses metabolic changes in the pancreatic
β-cell, thereby coupling metabolism to electrical activity and ultimately to insulin secretion. When
K ATP channels open, β-cells hyperpolarize and insulin secretion is suppressed. The ... Cited by 43 - Related articles - BL Direct - All 5 versions
J Bryan, WH Vila-Carriles, G Zhao, AP Babenko, L … - Diabetes, 2004 - Am Diabetes Assoc Advances in understanding the overall structural features of inward rectifiers and ATP-binding
cassette (ABC) transporters are providing novel insight into the architecture of ATP-sensitive
K + channels (K ATP channels) (K IR 6.0/SUR) 4 . The structure of the K IR pore has been ... Cited by 44 - Related articles - BL Direct - All 4 versions
J Bryan, A Crane, WH Vila-Carriles, AP … - Current …, 2005 - ingentaconnect.com Abstract: ATP-sensitive K + channels, termed K ATP channels, provide a link between cellular
metabolism and membrane electrical activity in a variety of tissues. Channel isoforms have been
identified and are targets for compounds that both stimulate and inhibit their activity ... Cited by 38 - Related articles - BL Direct - All 4 versions
