- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited
by intracellular ATP , play key physiological roles in many tissues. In
pancreatic β cells, these channels regulate glucose-dependent insulin ... Cited by 142 - Related articles - BL Direct - All 14 versions
AT Hattersley, FM Ashcroft - Diabetes, 2005 - Am Diabetes Assoc Closure of ATP-sensitive K + channels (K ATP channels) in response to
metabolically generated ATP or binding of sulfonylurea drugs stimulates insulin
release from pancreatic β-cells. Heterozygous gain-of-function mutations ... Cited by 138 - Related articles - BL Direct - All 10 versions
FM Gribble, F Reimann - Diabetologia, 2003 - Springer Hypoglycaemic agents such as sulphonylureas and the newer group of
“glinides” stimulate insulin secretion by closing ATP-sensitive potassium (K
ATP ) channels in pancreatic beta cells, but have varying cross-reac- ... Cited by 107 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org AL Gloyn, F Reimann, C Girard, EL Edghill, P … - Human molecular genetics, 2005 - Oxford Univ Press Neonatal diabetes can either remit and hence be transient or else may be
permanent. These two phenotypes were considered to be genetically distinct.
Abnormalities of 6q24 are the commonest cause of transient neonatal ... Cited by 88 - Related articles - All 7 versions
- ►oxfordjournals.org F Ashcroft, P Rorsman - Human molecular genetics, 2004 - Oxford Univ Press Type 2 diabetes mellitus is a serious metabolic disease that afflicts around 5%
of the population in Western societies and over 150 million people worldwide. It
is characterized by elevation of the blood glucose concentration, usually ... Cited by 70 - Related articles - All 5 versions
- ►diabetesjournals.org JC Koster, MA Permutt, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The ATP-sensitive K + channel (K ATP channel) senses metabolic changes in the
pancreatic β-cell, thereby coupling metabolism to electrical activity and
ultimately to insulin secretion. When K ATP channels open, β-cells ... Cited by 43 - Related articles - BL Direct - All 5 versions
AS Slingerland, AT Hattersley - Annals of Medicine, 2005 - informahealthcare.com Abstract Permanent neonatal diabetes (PNDM) is diagnosed in the first three
months of life and is a major management problem as patients require lifelong
insulin injections. Recently, activating mutations in the KCNJ11 gene which ... Cited by 43 - Related articles - All 7 versions
J Bryan, WH Vila-Carriles, G Zhao, AP … - Diabetes, 2004 - Am Diabetes Assoc Advances in understanding the overall structural features of inward rectifiers
and ATP-binding cassette (ABC) transporters are providing novel insight into the
architecture of ATP-sensitive K + channels (K ATP channels) (K IR 6.0/SUR) ... Cited by 44 - Related articles - BL Direct - All 4 versions
- ►thelightlab.ca [PDF] MJ Riedel, DC Steckley, PE Light - Human genetics, 2005 - Springer Abstract The ATP-sensitive potassium (KATP) channel couples membrane
excitability to cellular metabolism and is a critical mediator in the process of
glucose- stimulated insulin secretion. Increasing numbers of KATP channel ... Cited by 33 - Related articles - All 5 versions
AL Gloyn, J Siddiqui, S Ellard - Human mutation, 2006 - interscience.wiley.com The beta-cell ATP-sensitive potassium channel is a key component of
stimulus-secretion coupling in the pancreatic beta-cell. The channel couples
metabolism to membrane electrical events, bringing about insulin secretion. ... Cited by 32 - Related articles - BL Direct - All 3 versions
