AL Gloyn - Human mutation, 2003 - interscience.wiley.com Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a
crucial role in the regulation of insulin secretion and has been termed the
pancreatic beta-cell sensor. Given its central role in the regulation of ... Cited by 121 - Related articles - BL Direct - All 6 versions
S Del Guerra, R Lupi, L Marselli, M Masini, M … - Diabetes, 2005 - Am Diabetes Assoc To shed further light on the primary alterations of insulin secretion in type 2
diabetes and the possible mechanisms involved, we studied several functional and
molecular properties of islets isolated from the pancreata of 13 type 2 ... Cited by 107 - Related articles - All 5 versions
L Kang, VH Routh, EV Kuzhikandathil, LD … - Diabetes, 2004 - Am Diabetes Assoc To evaluate potential mechanisms for neuronal glucosensing, fura-2 Ca 2+ imaging
and single-cell RT-PCR were carried out in dissociated ventromedial hypothalamic
nucleus (VMN) neurons. Glucose-excited (GE) neurons increased and glucose- ... Cited by 94 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org PR Njølstad, JV Sagen, L Bjørkhaug, S Odili … - Diabetes, 2003 - Am Diabetes Assoc Neonatal diabetes can be either permanent or transient. We have recently shown
that permanent neonatal diabetes can result from complete deficiency of
glucokinase activity. Here we report three new cases of glucokinase-related ... Cited by 85 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org AL Gloyn, K Noordam, MAAP Willemsen, S … - Diabetes, 2003 - Am Diabetes Assoc Glucokinase (GCK) is a key regulatory enzyme in the pancreatic β-cell and
catalyzes the rate-limiting step for β-cell glucose metabolism. We report two
novel GCK mutations (T65I and W99R) that have arisen de novo in two ... Cited by 78 - Related articles - BL Direct - All 5 versions
- ►musc.edu [PDF] JJ Lemasters, E Holmuhamedov - BBA-Molecular Basis of Disease, 2006 - Elsevier Despite a detailed understanding of their metabolism, mitochondria often behave
anomalously. In particular, global suppression of mitochondrial metabolism and
metabolite exchange occurs in apoptosis, ischemia and anoxia, cytopathic ... Cited by 71 - Related articles - All 6 versions
- ►diabetesjournals.org AL Cuesta-Muñoz, H Huopio, T Otonkoski, JM … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) is a glycolytic key enzyme that functions as a glucose sensor
in the pancreatic β-cell, where it governs glucose-stimulated insulin secretion
(GSIS). Heterozygous inactivating mutations in the glucokinase gene (GCK) ... Cited by 69 - Related articles - BL Direct - All 5 versions
LE Fridlyand, LH Philipson - Diabetes, 2004 - Am Diabetes Assoc Glucose-dependent insulin secretion (GDIS), reactive oxygen species (ROS)
production, and oxidative stress in pancreatic β-cells may be tightly linked
processes. Here we suggest that the same pathways used in the activation of ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►endojournals.org AM Efanov, DG Barrett, MB Brenner, SL Briggs … - Endocrinology, 2005 - Endocrine Soc The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose
metabolism. We report here the effects of a novel glucokinase activator,
LY2121260. The activator enhanced GK activity via binding to the allosteric ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►endojournals.org A Wiederkehr, CB Wollheim - Endocrinology, 2006 - Endocrine Soc Mitochondria are essential for intermediary metabolism as well as energy
production in the cell. Their aerobic metabolism permits oxidation of glucose
and fatty acids for the generation of ATP and other intermediates that are ... Cited by 55 - Related articles - BL Direct - All 4 versions
