SE Kahn, RL Hull, KM Utzschneider - NATURE-LONDON-, 2006 - tesumassd.org The increased prevalence of obesity has focused attention on a world- wide problem that is not
one of famine or infection, but one of surplus. In the United States, only about a third of adults
are considered to be of 'normal' weight1, and similar trends are being observed ... Cited by 294 - Related articles - View as HTML - BL Direct - All 9 versions
- ►sallyosborne.com [PDF] JE Schaffer - Current opinion in lipidology, 2003 - journals.lww.com Recent findings: Excess lipid accumulation in non-adipose tissues may arise in the setting of
high plasma free fatty acids or triglycerides. Alternatively, lipid overload results from mismatch
between free fatty acid import and utilization. Evidence from human studies and animal ... Cited by 197 - Related articles - BL Direct - All 8 versions
- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in the pathogenesis
of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of β cell
compensation for insulin resistance, consideration is also given to the mechanisms ... Cited by 199 - Related articles - BL Direct - All 7 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R Roduit, S … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs)
together with hyperglycemia are synergistic in causing islet ß-cell damage because high glucose
inhibits fat oxidation and consequently lipid detoxification. The effects of 1–2 d culture of ... Cited by 174 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org H Kim, M Haluzik, Z Asghar, D Yau, JW Joseph, AM … - Diabetes, 2003 - Am Diabetes Assoc Abnormalities in insulin action are the characteristics of type 2 diabetes. Dominant-negative
muscle-specific IGF-I receptor (MKR) mice exhibit elevated lipid levels at an early age and eventually
develop type 2 diabetes. To evaluate the role of elevated lipids in the progression of the ... Cited by 110 - Related articles - BL Direct - All 4 versions
J Buteau, W El-Assaad, CJ Rhodes, L Rosenberg, E … - Diabetologia, 2004 - Springer Aims/hypothesis. We have provided evidence that gluca- gon-like peptide-1, a potential therapeutic
agent in the treatment of diabetes, activates phosphatidylinositol-3 kinase/protein kinase B signalling
in the pancreatic beta cell. Since this pathway promotes cell survival in a vari- ety of ... Cited by 113 - Related articles - BL Direct - All 4 versions
- ►physiology.org MJ Dunne, KE Cosgrove, RM Shepherd, A … - Physiological …, 2004 - Am Physiological Soc The earliest description of hyperinsulinism appears to have been that provided by Laidlaw in
1938 who used the term nesidioblastosis to describe the severe, recurrent hypoglycemia associated
with an inappropriate elevation of serum insulin, C-peptide, and proinsulin (161). While ... Cited by 108 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org YH Yu, HN Ginsberg - Circulation research, 2005 - Am Heart Assoc For many years adipose tissue was viewed as the site where excess energy was stored, in the
form of triglycerides (TGs), and where that energy, when needed elsewhere in the body, was
released in the form of fatty acids (FAs). Recently, it has become clear that when the ... Cited by 108 - Related articles - All 7 versions
JL Leahy - Archives of medical research, 2005 - Elsevier The pathological sequence for type 2 diabetes is complex and entails many different elements
that act in concert to cause that disease. This review proposes a sequence of events and how
they interact by a careful analysis of the human and animal model literature. A genetic ... Cited by 102 - Related articles - All 14 versions
- ►diabetesjournals.org R Roduit, C Nolan, C Alarcon, P Moore, A Barbeau, V … - Diabetes, 2004 - Am Diabetes Assoc The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin secretion
(GIIS) predicts that malonyl-CoA derived from glucose metabolism inhibits fatty acid
oxidation, thereby increasing the availability of LC-CoA for lipid signaling to cellular ... Cited by 89 - Related articles - BL Direct - All 7 versions
