- ►nih.gov YC Long, JR Zierath - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates
glucose uptake and lipid oxidation to produce energy, while turning off ... Cited by 166 - Related articles - BL Direct - All 9 versions
GA Rutter, GDS Xavier, I Leclerc - Biochemical Journal, 2003 - pubmedcentral.nih.gov AMPK (5 -AMP-activated protein kinase) is emerging as a meta- bolic master
switch, by which cells in both mammals and lower organisms sense and decode
changes in energy status. Changes in AMPK activity have been shown to ... Cited by 141 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org CB Chan, MC Saleh, V Koshkin, MB Wheeler - Diabetes, 2004 - Am Diabetes Assoc Stressors such as chronic hyperglycemia or hyperlipidemia may lead to
insufficient insulin secretion in susceptible individuals, contributing to type
2 diabetes. The molecules mediating this effect are just beginning to be ... Cited by 84 - Related articles - BL Direct - All 4 versions
S Winzell… - Diabetes, 2003 - Am Diabetes Assoc Lipid perturbations associated with triglyceride overstorage in β-cells impair
insulin secretion, a process termed lipotoxicity. To assess the role of
hormone-sensitive lipase, which is expressed and enzymatically active in β- ... Cited by 52 - Related articles - BL Direct - All 4 versions
- ►endojournals.org T Yamashita, K Eto, Y Okazaki, S Yamashita, … - Endocrinology, 2004 - Endocrine Soc Triglyceride (TG) accumulation in pancreatic ß-cells is thought to be
associated with impaired insulin secretory response to glucose (lipotoxicity).
To better understand the mechanism of the impaired insulin secretory ... Cited by 51 - Related articles - BL Direct - All 3 versions
- ►endocrinology-journals.org SK Richards, LE Parton, I Leclerc, GA Rutter, … - Journal of Endocrinology, 2005 - Soc Endocrinology Treatment of type 1 diabetes by islet transplantation is currently limited by
loss of functional ß-cell mass after transplantation. We investigated here
whether adenovirus-mediated changes in AMP-activated protein kinase (AMPK) ... Cited by 45 - Related articles - BL Direct - All 6 versions
GA Rutter - Diabetologia, 2004 - Springer Insulin secretion from pancreatic islet beta cells is a tightly regulated
process, under the close control of blood glucose concentrations, neural inputs
and circu- lating hormones. Defects in glucose-triggered insulin secretion, ... Cited by 35 - Related articles - All 6 versions
I Leclerc, GA Rutter - Diabetes, 2004 - Am Diabetes Assoc Stimulation of AMP-activated protein kinase (AMPK) in skeletal muscle and liver
is seen as an exciting prospect for the treatment of type 2 diabetes. However,
we have recently demonstrated that changes in AMPK activity accompany the ... Cited by 28 - Related articles - BL Direct - All 5 versions
G da Silva Xavier, J Rutter, GA Rutter - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences Per–Arnt–Sim (PAS) domain-containing kinases are common in prokaryotes, but
a mammalian counterpart has only recently been described. Although the PAS
domain of the mammalian PAS kinase (PASK) is closely related to the ... Cited by 26 - Related articles - BL Direct - All 11 versions
