- ►physiology.org MJ Dunne, KE Cosgrove, RM Shepherd, A … - Physiological reviews, 2004 - Am Physiological Soc The earliest description of hyperinsulinism appears to have been that provided
by Laidlaw in 1938 who used the term nesidioblastosis to describe the severe,
recurrent hypoglycemia associated with an inappropriate elevation of serum ... Cited by 108 - Related articles - BL Direct - All 3 versions
- ►endojournals.org A Wiederkehr, CB Wollheim - Endocrinology, 2006 - Endocrine Soc Mitochondria are essential for intermediary metabolism as well as energy
production in the cell. Their aerobic metabolism permits oxidation of glucose
and fatty acids for the generation of ATP and other intermediates that are ... Cited by 53 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org MC Sugden, MJ Holness - Diabetes, 2004 - Am Diabetes Assoc In this review, we discuss the influence of peroxisome proliferator-activated
receptor (PPAR)-α on islet insulin secretion and develop the hypothesis that
modulation of PPAR-α function may be important for the regulation of ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►unige.ch [PDF] P Maechler, S Carobbio, B Rubi - International Journal of Biochemistry and Cell Biology, 2006 - Elsevier Pancreatic beta-cells are unique neuroendocrine cells displaying the peculiar
feature of responding to nutrients, principally glucose, as primary stimulus.
This requires translation of a metabolic substrate into intracellular ... Cited by 29 - Related articles - All 7 versions
DD De León, CA Stanley - Nature Clinical Practice Endocrinology & Metabolism, 2007 - nature.com Diva D De León is an Assistant Professor of Pediatrics at the University of
Pennsylvania, Philadelphia, PA, USA, and an Attending Physician in the Division
of Endocrinology, The Children's Hospital of Philadelphia. Her research ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►physiology.org YJ Liu, H Cheng, H Drought, MJ MacDonald, … - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc Leucine and glutamine were used to elicit biphasic insulin release in rat
pancreatic islets. Leucine did not mimic the full biphasic response of glucose.
Glutamine was without effect. However, the combination of the two did mimic ... Cited by 25 - Related articles - BL Direct - All 4 versions
F Reimann, L Williams, G da Silva Xavier, GA … - Diabetologia, 2004 - Springer Aims/hypothesis. Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are
secreted from enteroendocrine L cells in response to nutrient ingestion. As
glutamine is an important metabolic fuel for the gut, the aim of this study ... Cited by 23 - Related articles - BL Direct - All 6 versions
KE Cosgrove, RM Shepherd, EM Fernandez, A … - Horm Res, 2004 - content.karger.com Hyperinsulinism in infancy (HI) is a condition of neonates and early childhood.
For many years the pathophysiology of this potentially lethal disorder was
unknown. Advances in the genetics, histopathology and molecular physiology ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►unige.ch [PDF] S Carobbio, H Ishihara, S Fernandez-Pascual, … - Diabetologia, 2004 - Springer Aims/hypothesis. Glutamate dehydrogenase (GDH) is a mitochondrial enzyme playing
a key role in the con- trol of insulin secretion. However, it is not known
whether GDH expression levels in beta cells are rate- limiting for the ... Cited by 10 - Related articles - BL Direct - All 6 versions
- ►physiology.org T Anno, S Uehara, H Katagiri, Y Ohta, K … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Glutamate dehydrogenase (GDH) catalyzes reversible oxidative deamination of
L-glutamate to -ketoglutarate. Enzyme activity is regulated by several
allosteric effectors. Recognition of a new form of hyperinsulinemic ... Cited by 9 - Related articles - BL Direct - All 4 versions
