- ►diabetesjournals.org GG Holz - Diabetes, 2004 - Am Diabetes Assoc Recently published studies of islet cell function reveal unexpected features of glucagon-like
peptide-1 (GLP-1) receptor-mediated signal transduction in the pancreatic β-cell. Although
GLP-1 is established to be a cAMP-elevating agent, these studies demonstrate that ... Cited by 127 - Related articles - BL Direct - All 6 versions
- ►bcell.org [PDF] PE MacDonald, MB Wheeler - Diabetologia, 2003 - Springer Insulin secretion from pancreatic islet beta cells is acutely regulated by a complex interplay of
metabolic and electrogenic events. The electrogenic mechanism regulating insulin secretion
from beta cells is com- monly referred to as the ATP-sensitive K ... Keywords Channels, ... Cited by 74 - Related articles - BL Direct - All 4 versions
- ►glucagon.com [PDF] T Hansotia, DJ Drucker - Regulatory peptides, 2005 - Elsevier Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are
gut-derived incretins secreted in response to nutrient ingestion. Both incretins potentiate
glucose-dependent insulin secretion and enhance β-cell mass through regulation of ... Cited by 48 - Related articles - All 5 versions
- ►endojournals.org DD Feng, Z Luo, S Roh, M Hernandez, N Tawadros, DJ … - Endocrinology, 2006 - Endocrine Soc Free fatty acids (FFAs), in addition to glucose, have been shown to stimulate insulin release through
the G protein-coupled receptor (GPCR)40 receptor in pancreatic ß-cells. Intracellular free calcium
concentration ([Ca 2+ ] i ) in ß-cells is elevated by FFAs, although the mechanism ... Cited by 41 - Related articles - BL Direct - All 5 versions
- ►physiology.org DA D'Alessio, TP Vahl - American Journal of Physiology- …, 2004 - Am Physiological Soc Glucagon-like peptide 1 (GLP-1) is a product of proglucagon that is secreted by specialized intestinal
endocrine cells after meals. GLP-1 is insulinotropic and plays a role in the incretin effect, the
augmented insulin response observed when glucose is absorbed through the gut. GLP-1 ... Cited by 37 - Related articles - BL Direct - All 4 versions
L Yan, DJ Figueroa, CP Austin, Y Liu, RM Bugianesi, … - Diabetes, 2004 - Am Diabetes Assoc Voltage-gated potassium channels (Kv channels) are involved in repolarization of excitable
cells. In pancreatic β-cells, prolongation of the action potential by block of delayed rectifier potassium
channels would be expected to increase intracellular free calcium and to promote insulin ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►jbc.org PE MacDonald, X Wang, F Xia, W El-kholy, ED … - Journal of Biological …, 2003 - ASBMB Antagonism of voltage-dependent K + (Kv) currents in pancreatic -cells may contribute to the
ability of glucagon-like peptide-1 (GLP-1) to stimulate insulin secretion. The mechanism and
signaling pathway regulating these currents in rat -cells were investigated using the ... Cited by 30 - Related articles - BL Direct - All 4 versions
J Gromada, B Brock, O Schmitz, P … - Basic & Clinical …, 2004 - interscience.wiley.com Abstract: Glucagon-like peptide-1 (GLP-1) is an intestinally derived insulinotropic hormone currently
under investigation for use as a novel therapeutic agent in the treatment of type 2 diabetes. One
of several important effects of GLP-1 is on nutrient-induced pancreatic hormone release ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►physiology.org E Muscelli, A Mari, A Natali, BD Astiarraga … - American Journal of …, 2006 - Am Physiological Soc The mechanisms by which the enteroinsular axis influences -cell function have not been investigated
in detail. We performed oral and isoglycemic intravenous (IV) glucose administration in subjects
with normal (NGT; n = 11) or impaired glucose tolerance (IGT; n = 10), using C-peptide ... Cited by 20 - Related articles - BL Direct - All 4 versions
PE MacDonald, AMF Salapatek, MB … - The Journal of …, 2003 - Physiological Soc In pancreatic β-cells, voltage-dependent K + (Kv) channels repolarise glucose-stimulated action
potentials. Kv channels are therefore negative regulators of Ca 2+ entry and insulin
secretion. We have recently demonstrated that Kv2.1 mediates the majority of β-cell ... Cited by 18 - Related articles - BL Direct - All 6 versions
