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Scholar Results 1 - 10 of about 26 citing Efendic: Two generations of insulinotropic imidazoline compounds. (0.09 sec) 

[CITATION] Hierarchy of the beta-cell signals controlling insulin secretion


JC Henquin, MA Ravier, M Nenquin, JC Jonas … - European Journal of Clinical Investigation, 2003 - journals.indexcopernicus.com
logo IndexCopernicus, Current language: English. IC Journals Master List. Journal
of the Week. Journals Master List. Journals from CC list. ...
Cited by 78 - Related articles - BL Direct - All 4 versions

Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin …

- diabetesjournals.org
JC Henquin - Diabetes, 2004 - Am Diabetes Assoc
Physiologically, insulin secretion is subject to a dual, hierarchal control by
triggering and amplifying pathways. By closing ATP-sensitive K + channels (K ATP
channels) in the plasma membrane, glucose and other metabolized nutrients ...
Cited by 37 - Related articles - BL Direct - All 4 versions

Blockade of sympathetic nervous system activity by rilmenidine increases plasma adiponectin …


Ł Nowak, M Adamczak, A Więcek - American journal of hypertension, 2005 - Elsevier
Adiponectin is an adipose tissue-specific protein with antiatherogenic and
insulin-sensitizing properties. In patients with essential hypertension plasma
adiponectin levels are lower than in healthy subjects. It is hypothetized ...
Cited by 26 - Related articles - All 4 versions

Desensitization of insulin secretion by depolarizing insulin secretagogues

- diabetesjournals.org
I Rustenbeck, A Wienbergen, C Bleck, A Jörns - Diabetes, 2004 - Am Diabetes Assoc
Prolonged stimulation of insulin secretion by depolarization and Ca 2+ influx
regularly leads to a reversible state of decreased secretory responsiveness to
nutrient and nonnutrient stimuli. This state is termed "desensitization." ...
Cited by 13 - Related articles - BL Direct - All 4 versions

Glucose Dependence of Imidazoline-Induced Insulin Secretion


C Bleck, A Wienbergen, I Rustenbeck - Diabetes, 2004 - Am Diabetes Assoc
The glucose dependence of the insulinotropic action of K ATP channel–blocking
imidazoline compounds was investigated. Administration of 100 μmol/l
phentolamine, but not 100 μmol/l efaroxan, markedly increased insulin ...
Cited by 9 - Related articles - BL Direct - All 5 versions

Interleukin (IL)-1beta toxicity to islet beta cells: Efaroxan exerts a complete protection.


G Papaccio, A Graziano, S Valiante, R d'Aquino, … - Journal of cellular physiology, 2005 - ncbi.nlm.nih.gov
Interleukin (IL)-1beta-treated rat islets of Langerhans were exposed in vitro
either to the imidazoline compound, Efaroxan, or to the selective inducible
nitric oxide synthase (iNOS) inhibitor, 1400W, in a medium containing a ...
Cited by 9 - Related articles - All 4 versions

Essential role of the imidazoline moiety in the insulinotropic effect but not the K ATP …


C Bleck, A Wienbergen, I Rustenbeck - Diabetologia, 2005 - Springer
Abstract Aims/hypothesis: Imidazolines are a class of investigational
antidiabetic drugs. It is still unclear whether the imidazoline ring is decisive
for insulinotropic char- acteristics. Materials and methods: We studied the ...
Cited by 9 - Related articles - BL Direct - All 4 versions

Metabolic effects of antihypertensive agents: role of sympathoadrenal and renin- …


P Ernsberger, RJ Koletsky - Naunyn-Schmiedeberg's Archives of Pharmacology, 2006 - Springer
Abstract Reports of beneficial, neutral and adverse impacts of antihypertensive
drug classes on glucose and lipid metabolism can be found in human data.
Furthermore, mechanisms for these diverse effects are often speculative and ...
Cited by 8 - Related articles - BL Direct - All 3 versions

Comparative effects of efaroxan and b-carbolines on the secretory activity of rodent and …


NG MORGAN, EJ COOPER, PE SQUIRES, CE … - Annals of the New York Academy of Sciences, 2003 - interscience.wiley.com
Abstract: The pancreatic b-cell expresses an imidazoline-binding site that is
involved in the regulation of insulin secretion. This site is pharmacologically
atypical in comparison with the I 1 and I 2 sites described in other ...
Cited by 7 - Related articles - BL Direct - All 4 versions

Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X


RA Velliquette, R Kossover, SF Previs, P … - Naunyn-Schmiedeberg's archives of pharmacology, 2006 - Springer
Page 1. Naunyn-Schmiedeberg's Arch Pharmacol (2006) 372: 300–312 DOI 10.1007/s00210-
005-0024-3 ORIGINAL ARTICLE Rodney A. Velliquette . Rachel Kossover . ...
Cited by 6 - Related articles - BL Direct - All 5 versions


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