S Oyadomari, M Mori - Cell Death & Differentiation, 2003 - nature.com Endoplasmic reticulum (ER) is the site of synthesis and folding of secretory
proteins. Perturbations of ER homeostasis affect protein folding and cause ER
stress. ER can sense the stress and respond to it through translational ... Cited by 386 - Related articles - BL Direct - All 4 versions
G Stoecklin, T Stubbs, N Kedersha, S Wax, … - The EMBO Journal, 2004 - pubmedcentral.nih.gov Stress granules (SGs) are dynamic cytoplasmic foci at which stalled translation
initiation complexes accumulate in cells subjected to environmental stress.
SG-associated proteins such as TIA-1, TIAR and HuR bind to AU-rich element ... Cited by 151 - Related articles - All 8 versions
H Yoshida - FEBS journal, 2007 - human.cornell.edu Proteins synthesized in the endoplasmic reticulum (ER) are properly folded with
the assistance of ER chaperones. Malfolded proteins are disposed of by
ER-associated protein degradation (ERAD). When the amount of unfolded ... Cited by 154 - Related articles - View as HTML - BL Direct - All 7 versions
Y Nakatani, H Kaneto, D Kawamori, K … - Journal of Biological Chemistry, 2005 - ASBMB Type 2 diabetes is one of the most prevalent and serious metabolic diseases in
the world, and insulin resistance and pancreatic -cell dysfunction are the
hallmarks of the disease. In this study, we have shown that endoplasmic ... Cited by 144 - Related articles - All 5 versions
MY Donath, PA Halban - Diabetologia, 2004 - Springer Increasing evidence indicates that decreased functional beta-cell mass is the
hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or
relative insu- lin insufficiency in both conditions. In this For Debate, we ... Cited by 123 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org GS Hotamisligil - Diabetes, 2005 - Am Diabetes Assoc Metabolic and immune systems are the most fundamental requirements for survival,
and many metabolic and immune response pathways or nutrient- and
pathogen-sensing systems have been evolutionarily highly conserved. ... Cited by 104 - Related articles - BL Direct - All 7 versions
- ►pubget.com [PDF] DR Laybutt, AM Preston, MC Åkerfeldt, JG … - Diabetologia, 2007 - Springer Page 1. ARTICLE Endoplasmic reticulum stress contributes to beta cell apoptosis
in type 2 diabetes DR Laybutt & AM Preston & MC Åkerfeldt & ... Cited by 103 - Related articles - BL Direct - All 5 versions
JL Leahy - Archives of medical research, 2005 - Elsevier The pathological sequence for type 2 diabetes is complex and entails many
different elements that act in concert to cause that disease. This review
proposes a sequence of events and how they interact by a careful analysis ... Cited by 102 - Related articles - All 14 versions
- ►wustl.edu [PDF] L Zhao, SL Ackerman - Current opinion in cell biology, 2006 - Elsevier Unfolded proteins and other conditions affecting endoplasmic reticulum (ER)
homeostasis cause ER stress. The cell reacts to ER stress by activation of the
unfolded protein response (UPR), which induces profound changes in cellular ... Cited by 100 - Related articles - All 6 versions
- ►endojournals.org E Karaskov, C Scott, L Zhang, T Teodoro, M … - Endocrinology, 2006 - Endocrine Soc Chronic free fatty acid (FFA) exposure induces pancreatic ß-cell death, which
may contribute to the development of type 2 diabetes. The mechanisms involved in
FFA-induced cell death are not completely understood. Here we have ... Cited by 95 - Related articles - BL Direct - All 4 versions
