MY Donath, J Størling, K Maedler, T Mandrup- … - Journal of Molecular …, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute
or relative insulin deficiency. β-cell death in type 1 diabetes is due predominantly to
autoimmunity. In type 2 diabetes β-cell death occurs as the combined consequence of ... Cited by 145 - Related articles - BL Direct - All 3 versions
S Norlin, U Ahlgren, H Edlund - Diabetes, 2005 - Am Diabetes Assoc Glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells depends on coordinated glucose
uptake, oxidative metabolism, and Ca 2+ -triggered insulin exocytosis. Impaired GSIS is a hallmark
of type 2 diabetes. However, at present we know very little about the molecular ... Cited by 42 - Related articles - All 7 versions
- ►jbc.org EB Hammar, JC Irminger, K Rickenbach, G … - Journal of Biological …, 2005 - ASBMB Laminin-5-rich extracellular matrix derived from 804G cells (804G-ECM) engages 1 integrins
to induce spreading, improve glucose-stimulated insulin secretion (GSIS), and increase survival
of pancreatic beta cells. The present study examines whether 804G-ECM activates the ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] JL Tomsig, H Sohma, CE Creutz - Biochemical Journal, 2004 - pubmedcentral.nih.gov The role of copines in regulating signalling from the TNF-α (tu- mour necrosis factor-α) receptor
was probed by the expression of a copine dominant-negative construct in HEK293 (human
embryo- nic kidney 293) cells. The construct was found to reduce activation of the ... Cited by 25 - Related articles - BL Direct - All 7 versions
- ►pnas.org DM Schumann, K Maedler, I Franklin, D … - Proceedings of the …, 2007 - National Acad Sciences Pancreatic β cell mass and function increase in conditions of enhanced insulin demand such
as obesity. Failure to adapt leads to diabetes. The molecular mechanisms controlling this adaptive
process are unclear. Fas is a death receptor involved in β cell apoptosis or proliferation, ... Cited by 21 - Related articles - BL Direct - All 11 versions
- ►uchile.cl [PDF] MA Carrasco, C Hidalgo - Cell Calcium, 2006 - Elsevier Neurons generate particular calcium microdomains in response to different stimuli. Calcium microdomains
have a central role in a variety of neuronal functions. In particular, calcium microdomains participate
in long-lasting synaptic plasticity—a neuronal response presumably correlated with ... Cited by 13 - Related articles - All 4 versions
- ►endojournals.org J Storling, SV Zaitsev, IL Kapelioukh, AE Karlsen, N … - Endocrinology, 2005 - Endocrine Soc The c-jun N-terminal kinase (JNK) signaling pathway mediates IL-1ß-induced apoptosis in
insulin-secreting cells, a mechanism relevant to the destruction of pancreatic ß-cells in type 1
and 2 diabetes. However, the mechanisms that contribute to IL-1ß activation of JNK in ß- ... Cited by 13 - Related articles - All 4 versions
- ►physiology.org JA Valdes, J Hidalgo, JL Galaz, N Puentes … - American Journal of …, 2007 - Am Physiological Soc Depolarization of skeletal muscle cells by either high external K + or repetitive extracellular field
potential pulses induces calcium release from internal stores. The two components of this release
are mediated by either ryanodine receptors or inositol 1,4,5-trisphosphate (IP 3 ) ... Cited by 12 - Related articles - BL Direct - All 8 versions
- ►rupress.org T Jordan, J Li, H Jiang, JX DiMario - Journal of Cell Biology, 2003 - jcb.rupress.org Gene expression in skeletal muscle fibers is regulated by innervation and intrinsic fiber
properties. To determine the mechanism of repression of slow MyHC2 expression in innervated
fast pectoralis major (PM) fibers, we investigated the function of the muscarinic ... Cited by 10 - Related articles - BL Direct - All 7 versions
K Maedler - Diabetes Obesity and Metabolism, 2008 - interscience.wiley.com The healthy β-cell has an enormous capacity to adapt to conditions of higher insulin demand
(eg in obesity, pregnancy, cortisol excess) to maintain normoglycaemia with an increase in its
functional β-cell mass. This compensates in 80–90% of individuals for insulin resistance. ... Cited by 7 - Related articles - BL Direct - All 4 versions
