L Levin, Y Tomer - Autoimmunity Reviews, 2003 - Elsevier Type 1 diabetes (T1D) and the autoimmune thyroid diseases (AITD) are the most
common autoimmune endocrine diseases. Both are organ-specific T-cell mediated
diseases. Abundant epidemiological data support a strong genetic basis for ... Cited by 42 - Related articles - All 2 versions
- ►ox.ac.uk [PDF] ES Venanzi, C Benoist, D Mathis - Current opinion in immunology, 2004 - Elsevier Clonal deletion is arguably the most important mechanism of eliminating
self-reactive thymocytes from the T-cell repertoire. Recent work has identified
new players in this process. On the thymocyte side, several molecules have ... Cited by 42 - Related articles - All 8 versions
E Melanitou, P Fain, GS Eisenbarth - Journal of Autoimmunity, 2003 - Elsevier Type 1A or immune mediated diabetes (T1 A D) is one of the most extensively
studied genetic diseases with a complex etiology. In the last decade, the major
challenge has been to identify the genes responsible for the disease. Data ... Cited by 18 - Related articles - All 4 versions
B Faideau, E Larger, F Lepault, JC Carel, C … - Diabetes, 2005 - Am Diabetes Assoc Whether autoimmunity results primarily from a defect of the immune system,
target organ dysfunction, or both remains an open issue in most human autoimmune
diseases. The highly multigenic background on which diabetes develops in ... Cited by 16 - Related articles - BL Direct - All 4 versions
F Homo-Delarche - ILAR J, 2004 - dels.nas.edu Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which
insulin-producing beta cells of the pancre- atic islets of Langerhans are
destroyed. The nonobese dia- betic (NOD) mouse is one of the rare ... Cited by 14 - Related articles - View as HTML - BL Direct - All 2 versions
J Chan, W Clements, J Field, Z Nasa, P Lock, … - Journal of Gene Medicine, 2006 - interscience.wiley.com Type 1 diabetes (T1D) is a T-cell-dependent autoimmune disease resulting from
destructive inflammation (insulitis) of the insulin-producing pancreatic -cells.
Transgenic expression of proinsulin II by a MHC class II promoter or ... Cited by 11 - Related articles - BL Direct - All 2 versions
- ►nih.gov J Villaseñor, W Besse, C Benoist, D Mathis - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Thymic medullary epithelial cells (MECs) express a broad repertoire of
peripheral-tissue antigens (PTAs), many of which depend on the transcriptional
regulatory factor Aire. Although Aire is known to be critically important ... Cited by 4 - Related articles - All 6 versions
Y Chang, S Yap, X Ge, J Piganelli, S … - Gene Therapy, 2005 - nature.com Type 1 diabetes (T1D), a T-cell-mediated autoimmune disease, could be attributed
to many defects in nonobese diabetic (NOD) mice, including deficient expressions
of costimulatory molecules that impair antigen presentation. Thus, this ... Cited by 3 - Related articles - BL Direct - All 4 versions
KD Hettiarachchi, PZ Zimmet, MA Myers - Current Diabetes Reviews, 2008 - ingentaconnect.com Abstract: The incidence of Type 1 diabetes has been increasing at a rate too
rapid to be due to changes in genetic risk. In- stead changes in environmental
factors are the likely culprit. The endoplasmic reticulum (ER) plays an ... Cited by 2 - Related articles - All 2 versions
V Judkowski, E Rodriguez, C Pinilla, E … - Clinical Immunology, 2004 - Elsevier NOD mice spontaneously develop insulitis and type 1 diabetes (T1D) mellitus
similar to humans. Insulitis without overt disease occurs in the BDC2.5
TCR-transgenic NOD mice that express the rearranged TCR α- and β-chain ... Cited by 1 - Related articles - All 3 versions
