- ►stuba.sk [PDF] M Valko, D Leibfritz, J Moncol, MTD Cronin, M … - International Journal of Biochemistry and Cell Biology, 2007 - Elsevier Reactive oxygen species (ROS) and reactive nitrogen species (RNS, eg nitric
oxide, NO ) are well recognised for playing a dual role as both deleterious and
beneficial species. ROS and RNS are normally generated by tightly regulated ... Cited by 695 - Related articles - All 9 versions
- ►ahajournals.org A Ceriello, E Motz - Arteriosclerosis, thrombosis, and vascular biology, 2004 - Am Heart Assoc Type 2 diabetes is a worldwide increasing disease resulting from the interaction
between a subject's genetic makeup and lifestyle. In genetically predisposed
subjects, the combination of excess caloric intake and reduced physical ... Cited by 388 - Related articles - BL Direct - All 9 versions
MY Donath, J Størling, K Maedler, T Mandrup … - Journal of Molecular Medicine, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes
mellitus, leading to absolute or relative insulin deficiency. β-cell death in
type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes ... Cited by 145 - Related articles - BL Direct - All 3 versions
PJ Havel - Nutrition reviews, 2005 - ingentaconnect.com Fructose intake and the prevalence of obesity have both increased over the past
two to three decades. Compared with glucose, the hepatic metabolism of fructose
favors lipogenesis, which may contribute to hyperlipidemia and obesity. ... Cited by 127 - Related articles - All 8 versions
- ►endojournals.org H Urakawa, A Katsuki, Y Sumida, EC Gabazza, … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc To investigate the direct relationship of oxidative stress with obesity and
insulin resistance in men, we measured the plasma levels of 8-epi-prostaglandin
F2 (PGF2 ) in 14 obese and 17 nonobese men and evaluated their relationship ... Cited by 119 - Related articles - BL Direct - All 4 versions
- ►uc.pt [PDF] AP Rolo, CM Palmeira - Toxicology and applied pharmacology, 2006 - Elsevier Hyperglycemia resulting from uncontrolled glucose regulation is widely
recognized as the causal link between diabetes and diabetic complications. Four
major molecular mechanisms have been implicated in hyperglycemia-induced ... Cited by 120 - Related articles - All 7 versions
H Kolb, T Mandrup-Poulsen - Diabetologia, 2005 - Springer Abstract Subclinical, low-grade systemic inflammation has been observed in
patients with type 2 diabetes and in those at increased risk of the disease.
This may be more than an epiphenomenon. Alleles of genes encoding immune/ ... Cited by 118 - Related articles - BL Direct - All 5 versions
SR Smith, F Bai, C Charbonneau, L … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance is a component of type 2 diabetes and often precedes
pancreatic β-cell failure. Contributing factors include obesity and a central
pattern of fat accumulation with a strong genetic component. The adipocyte ... Cited by 113 - Related articles - BL Direct - All 6 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in
skeletal muscle and the liver, and researchers have recently proposed two
mechanisms by which excess adiposity antagonizes insulin action in ... Cited by 114 - Related articles - All 3 versions
NK Parekh, LS Hynan, J De Lemos, WM Lee, P … - Hepatology, 2007 - journals.lww.com In the early stages of nonalcoholic fatty liver disease (NAFLD), triglycerides
accumulate in hepatocytes. Diacylglycerol acyltransferase 2 (DGAT2) catalyzes
the final step in hepatocyte triglyceride biosynthesis. DGAT2 antisense ... Cited by 101 - Related articles - BL Direct - All 4 versions
