J Machann, H Haring, F Schick, M Stumvoll - Diabetes Obesity and Metabolism, 2004 - interscience.wiley.com Lipids are stored not only in adipocytes but also 'ectopically' in tissues such
as muscle, liver, beta cells and others. From a metabolic perspective,
intramyocellular lipids (IMCLs) have recently become a focus of interest. ... Cited by 71 - Related articles - BL Direct - All 4 versions
- ►nih.gov PC Chui, HP Guan, M Lehrke, MA Lazar - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig In addition to its role in energy storage, adipose tissue also accumulates
cholesterol. Concentrations of cholesterol and triglycerides are strongly
correlated in the adipocyte, but little is known about mechanisms ... Cited by 59 - Related articles - BL Direct - All 15 versions
KL Wyne - The American journal of medicine, 2003 - Elsevier Acute elevation of plasma free fatty acids (FFAs) is necessary for insulin
secretion. Sustained elevation, however, leads to apoptosis of pancreatic
β-cells and is a major risk factor for cardiovascular disease and sudden ... Cited by 60 - Related articles - All 9 versions
- ►diabetesjournals.org XL Wang, L Zhang, K Youker, MX Zhang, J … - Diabetes, 2006 - Am Diabetes Assoc In metabolic syndrome, a systemic deregulation of the insulin pathway leads to a
combined deregulation of insulin-regulated metabolism and cardiovascular
functions. Free fatty acids (FFAs), which are increased in metabolic ... Cited by 48 - Related articles - BL Direct - All 4 versions
AR Vasudevan, A Balasubramanyam - Diabetes Technology & Therapeutics, 2004 - liebertonline.com The thiazolidinediones (TZDs) rosiglitazone and pioglitazone are newer additions
to the an- tidiabetic armamentarium and are indicated for the treatment of type
2 diabetes mellitus (T2DM) in the United States. The TZDs are peroxisome ... Cited by 45 - Related articles - All 3 versions
- ►endojournals.org SJ Lessard, SLL Giudice, W Lau, JJ Reid, N … - Endocrinology, 2004 - Endocrine Soc We hypothesized that improved glucose tolerance with rosiglitazone treatment
would coincide with decreased levels of im triacylglycerol (IMTG),
diacylglycerol, and ceramide. Obese Zucker rats were randomly divided into ... Cited by 29 - Related articles - BL Direct - All 5 versions
EL Thomas, AE Brynes, G Hamilton, N Patel, A … - WORLD JOURNAL OF GASTROENTEROLOGY, 2006 - wjg.wjgnet.com RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4%
(-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT)
depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and ... Cited by 27 - Related articles - Cached - BL Direct - All 8 versions
KJ Nadeau, JW Leitner, I Gurerich, B Draznin - Journal of Biological Chemistry, 2004 - ASBMB Sterol regulatory element-binding proteins (SREBPs) are transcription factors
that regulate enzymes required for cholesterol and fatty acid synthesis.
Expression of SREBP-1 is enhanced by insulin; however, the actual insulin- ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►physiology.org M Korach-Andre, J Gao, JS Gounarides, R … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc High visceral adiposity and intramyocellular lipid levels (IMCL) are both
associated with the development of type 2 diabetes. The relationship between
visceral adiposity and IMCL levels was explored in diet- and glucocorticoid- ... Cited by 20 - Related articles - All 4 versions
