- ►endojournals.org AM Vincent, JW Russell, P Low, EL Feldman - Endocrine reviews, 2004 - Endocrine Soc Oxidative stress results from a cell or tissue failing to detoxify the free radicals that are produced
during metabolic activity. Diabetes is characterized by chronic hyperglycemia that produces dysregulation
of cellular metabolism. This review explores the concept that diabetes overloads glucose ... Cited by 139 - Related articles - BL Direct - All 6 versions
- ►nih.gov EL Feldman - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Diabetes has reached epidemic proportions in the Western world. In the United States, 17 million
individuals have diabetes, greater than 6% of the population (1). The morbidity and mortality
of diabetes is due to the development of both macrovascular and microvascular ... Cited by 105 - Related articles - BL Direct - All 9 versions
IG Obrosova, F Li, OI Abatan, MA Forsell, K Komjáti, P … - Diabetes, 2004 - Am Diabetes Assoc Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy, but
the mechanisms remain unidentified. Here we provide evidence that poly(ADP-ribose) polymerase
(PARP) activation, a downstream effector of oxidant-induced DNA damage, is an ... Cited by 88 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org C Cheng, DW Zochodne - Diabetes, 2003 - Am Diabetes Assoc Long-term experimental diabetes may best model the prominent and irreversible sensory deficits
of chronic human diabetic polyneuropathy. Whereas irretrievable loss of sensory neurons, if
present, would be an unfortunate feature of the disease, systematic unbiased counting ... Cited by 79 - Related articles - BL Direct - All 4 versions
WM Campana, RR Myers - European Journal of Neuroscience, 2003 - interscience.wiley.com Erythropoietin (Epo) has been shown to have potent anti-apoptotic activity in central nervous
system neurons in animal models of ischaemic injury. Recently, Epo and its receptor (EpoR)
have been identified in the peripheral nervous system [Campana & Myers (2001), FASEB ... Cited by 75 - Related articles - BL Direct - All 6 versions
AM Vincent, JA Olzmann, M Brownlee, WI Sivitz, JW … - Diabetes, 2004 - Am Diabetes Assoc The central role of mitochondria in most pathways leading to programmed cell death (PCD) has
focused our investigations into the mechanisms of glucose-induced neuronal degeneration.
It has been postulated that hyperglycemic neuronal injury results from mitochondria ... Cited by 72 - Related articles - BL Direct - All 4 versions
G Davì, A Falco, C Patrono - Antioxidants & Redox Signaling, 2005 - liebertonline.com T HE PREVALENCE OF DIABETES MELLITUS (DM), a metabolic disorder characterized by
high levels of blood glucose and insufficient secretion or action of endogenous insulin, is increasing
worldwide (8, 9). It represents a major cause of morbidity in Western countries and, ... Cited by 69 - Related articles - All 4 versions
M Namaka, CR Gramlich, D Ruhlen, M Melanson, I … - Clinical therapeutics, 2004 - Elsevier Background: Neuropathic pain is a chronic pain syndrome caused by drug-, disease-, or
injury-induced damage or destruction of sensory neurons within the dorsal root ganglia of the
peripheral nervous system. Characteristic clinical symptoms include the feeling of pins ... Cited by 67 - Related articles - All 3 versions
S Cellek, NA Foxwell, S Moncada - Diabetes, 2003 - Am Diabetes Assoc The distinction between metabolic and structural changes occurring in autonomic neurons during
diabetes has not been fully clarified. Here we demonstrate that nitric oxide synthase-containing
(nitrergic) neurons innervating the penis and gastric pylorus of streptozotocin-induced ... Cited by 65 - Related articles - BL Direct - All 4 versions
MM Backonja, J Serra - Pain medicine, 2004 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 60 - Related articles - BL Direct - All 6 versions
