- ►physiology.org A Nandi, Y Kitamura, CR Kahn, D Accili - Physiological reviews, 2004 - Am Physiological Soc Type 2 diabetes results from a combination of insulin resistance and impaired
insulin secretion (203). The two abnormalities are intertwined, but in most
individuals the onset of insulin resistance precedes overt -cell ... Cited by 101 - Related articles - BL Direct - All 3 versions
PJ Klover, AH Clementi, RA Mooney - Endocrinology, 2005 - Endocrine Soc Obesity and insulin resistance are considered chronic inflammatory states, in
part because circulating IL-6 is elevated. Exogenous IL-6 can induce hepatic
insulin resistance in vitro and in vivo. The importance of endogenous IL-6, ... Cited by 93 - Related articles - BL Direct - All 5 versions
KK Bence, M Delibegovic, B Xue, CZ Gorgun, … - Nature medicine, 2006 - leptinresearch.org Obesity is a major health problem and a risk factor for type 2 diabetes. Leptin,
an adipocyte-secreted hormone, acts on the hypothalamus to inhibit food intake
and increase energy expenditure. Most obese individuals develop ... Cited by 89 - Related articles - View as HTML - BL Direct - All 10 versions
B Cariou, K van Harmelen, D Duran-Sandoval, … - Journal of Biological Chemistry, 2006 - ASBMB The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor
that plays a major role in the regulation of BA and lipid metabolism. Recently,
several studies have suggested a potential role of FXR in the control of ... Cited by 69 - Related articles - BL Direct - All 7 versions
JM Zabolotny, FG Haj, YB Kim, HJ Kim, GI … - Journal of Biological Chemistry, 2004 - ASBMB Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte
antigen-related phosphatase (LAR) as negative regulators of insulin signaling.
The expression and/or activity of PTP1B and LAR are increased in muscle of ... Cited by 55 - Related articles - BL Direct - All 8 versions
- ►nih.gov C Kurlawalla-Martinez, B Stiles, Y Wang, SU … - Molecular and Cellular Biology, 2005 - Am Soc Microbiol In adipose tissue, insulin controls glucose and lipid metabolism through the
intracellular mediators phosphatidylinositol 3-kinase and serine-threonine
kinase AKT. Phosphatase and a tensin homolog deleted from chromosome 10 ... Cited by 52 - Related articles - All 8 versions
Y Liang, MC Osborne, BP Monia, S Bhanot, … - Diabetes, 2004 - Am Diabetes Assoc Excess glucagon levels contribute to the hyperglycemia associated with type 2
diabetes. Reducing glucagon receptor expression may thus ameliorate the
consequences of hyperglucagonemia and improve blood glucose control in ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►nih.gov S Galic, C Hauser, BB Kahn, FG Haj, BG Neel, … - Molecular and Cellular Biology, 2005 - Am Soc Microbiol The protein tyrosine phosphatase PTP1B is a negative regulator of insulin
signaling and a therapeutic target for type 2 diabetes. Our previous studies
have shown that the closely related tyrosine phosphatase TCPTP might also ... Cited by 47 - Related articles - All 11 versions
GJ Cooney, RJ Lyons, AJ Crew, TE Jensen, JC … - The EMBO Journal, 2004 - pubmedcentral.nih.gov Gene targeting was used to characterize the physiological role of growth factor
receptor-bound (Grb)14, an adapter-type signalling protein that associates with
the insulin receptor (IR). Adult male Grb14 −/− mice displayed improved ... Cited by 42 - Related articles - BL Direct - All 6 versions
D Chen, MW Wang - Diabetes Obesity and Metabolism, 2005 - interscience.wiley.com The increasing worldwide incidence of diabetes in adults constitutes a global
public health burden. It is predicted that by 2025, India, China and the United
States will have the largest number of people with diabetes [1]. According ... Cited by 43 - Related articles - All 4 versions
