- ►nih.gov L Poirot, C Benoist, D Mathis - Proceedings of the National …, 2004 - National Acad Sciences In both human patients and murine models, the progression from insulitis to diabetes is neither
immediate nor inevitable, as illustrated by the innocuous versus destructive infiltrates of
BDC2.5 transgenic mice on the nonobese diabetic (NOD) versus C57BL/6.H-2 g 7 ... Cited by 60 - Related articles - BL Direct - All 9 versions
- ►jimmunol.org LM Esteban, T Tsoutsman, MA Jordan, D … - The Journal of …, 2003 - Am Assoc Immnol Natural killer T cells are an immunoregulatory population of lymphocytes that plays a critical
role in controlling the adaptive immune system and contributes to the regulation of autoimmune
responses. We have previously reported deficiencies in the numbers and function of NKT ... Cited by 35 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org N Martin-Orozco, Z Chen, L Poirot, E Hyatt, A … - The Journal of …, 2003 - Am Assoc Immnol Costimulatory signals received by diabetogenic T cells during priming by or upon secondary
encounter with autoantigen are decisive in determining the outcome of autoimmune attack. The
OX40-OX40 ligand (OX40L) costimulatory pathway is known to influence T cell ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►endojournals.org SM Clee, AD Attie - Endocrine reviews, 2007 - Endocrine Soc Inbred mouse strains provide genetic diversity comparable to that of the human population. Like
humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse strains
differ in the response of their critical physiological functions, such as insulin sensitivity, ... Cited by 29 - Related articles - BL Direct - All 4 versions
Y Yang, P Santamaria - Diabetologia, 2003 - Springer Type 1 diabetes results from a genetically and immu- nologically complex autoimmune process
that is spe- cifically directed against the pancreatic beta cells. Non-obese diabetic mice spontaneously
develop a form of autoimmune diabetes closely resembling the disease in humans. This ... Cited by 21 - Related articles - BL Direct - All 4 versions
RJ Chaparro, Y Konigshofer, GF Beilhack … - Proceedings of the …, 2006 - National Acad Sciences Before the onset of autoimmune destruction, type 1 diabetic patients and an animal model, the
nonobese diabetic (NOD) mouse, show morphological and functional abnormalities in target
organs, which may act as inciting events for leukocyte infiltration. To better understand ... Cited by 21 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org EP Blankenhorn, L Rodemich, C Martin-Fernandez, J … - Diabetes, 2005 - Am Diabetes Assoc BBDR rats develop autoimmune diabetes only after challenge with environmental
perturbants. These perturbants include polyinosinic:polycytidylic acid (poly I:C, a ligand of
toll-like receptor 3), agents that deplete regulatory T-cell (Treg) populations, and a non–β- ... Cited by 12 - Related articles - All 6 versions
NJ Armstrong, TC Brodnicki, TP Speed - Mammalian Genome, 2006 - Springer Abstract The development of congenic mouse strains is the principal approach for confirming
and fine mapping quantitative trait loci, as well as for comparing the phenotypic effect of a transgene
or gene-targeted disruption between different inbred mouse strains. The traditional ... Cited by 10 - Related articles - BL Direct - All 3 versions
TC Brodnicki, AL Fletcher, DG Pellicci, SP Berzins, P … - Diabetes, 2005 - Am Diabetes Assoc Congenic mouse strains provide a unique resource for genetic dissection and biological characterization
of chromosomal regions associated with diabetes progression in the nonobese diabetic
(NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a ... Cited by 4 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org N Yokoi, C Hayashi, Y Fujiwara, HY Wang, S Seino - Diabetes, 2007 - Am Diabetes Assoc The Komeda diabetes-prone (KDP) rat is an animal model of human autoimmune type 1
diabetes. We have previously shown that two major susceptibility genes, the major histocompatibility
complex (MHC) RT1 u haplotype and Cblb (Casitas B-lineage lymphoma b) mutation, are ... Cited by 4 - Related articles - BL Direct - All 5 versions
