GA Rutter, GDS Xavier, I Leclerc - Biochemical Journal, 2003 - pubmedcentral.nih.gov AMPK (5 -AMP-activated protein kinase) is emerging as a meta- bolic master
switch, by which cells in both mammals and lower organisms sense and decode
changes in energy status. Changes in AMPK activity have been shown to ... Cited by 141 - Related articles - BL Direct - All 8 versions
T Katome, T Obata, R Matsushima, N Masuyama … - Journal of Biological Chemistry, 2003 - ASBMB Insulin plays a central role in the regulation of glucose homeostasis in part by
stimulating glucose uptake and glycogen synthesis. The serine/threonine protein
kinase Akt has been proposed to mediate insulin signaling in several ... Cited by 127 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org D Nagata, R Takeda, M Sata, H Satonaka, E … - Circulation, 2004 - Am Heart Assoc Methods and Results— Aminoimidazole-4-carboxamide-1-ß-ribofuranoside (AICAR)
activated AMPK in rat VSMCs and inhibited Ang II-induced extracellular
signal-regulated kinase 1/2 phosphorylation but not that of p38 MAPK or ... Cited by 74 - Related articles - BL Direct - All 7 versions
SB Jørgensen, JN Nielsen, JB Birk, GS Olsen, … - Diabetes, 2004 - Am Diabetes Assoc The 5'AMP-activated protein kinase (AMPK) is a potential antidiabetic drug
target. Here we show that the pharmacological activation of AMPK by
5-aminoimidazole-1-ß-4-carboxamide ribofuranoside (AICAR) leads to ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org JS Sidhu, YS Rajawat, TG Rami, MH Gollob, Z … - Circulation, 2005 - Am Heart Assoc Methods and Results— To elucidate the molecular basis for the phenotype,
transgenic mice were generated by cardiac-restricted expression of the wild-type
(TG WT ) and mutant(TG R302Q ) PRKAG2 gene with the cardiac-specific ... Cited by 63 - Related articles - All 8 versions
- ►ahajournals.org M Arad, CE Seidman, JG Seidman - Circulation research, 2007 - Am Heart Assoc AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that is expressed
in most mammalian tissues including cardiac muscle. Among the multiple
biological processes influenced by AMPK, regulation of fuel supply and ... Cited by 61 - Related articles - All 6 versions
- ►endojournals.org C Bouche, S Serdy, CR Kahn, AB Goldfine - Endocrine reviews, 2004 - Endocrine Soc Type 2 diabetes is a complex disorder with diminished insulin secretion and
insulin action contributing to the hyperglycemia and wide range of metabolic
defects that underlie the disease. The contribution of glucose metabolic ... Cited by 51 - Related articles - BL Direct - All 6 versions
- ►nih.gov SB Jørgensen, EA Richter, JFP Wojtaszewski - The Journal of physiology, 2006 - Physiological Soc The 5′-AMP-activated protein kinase (AMPK) is a potent regulator of skeletal
muscle metabolism and gene expression. AMPK is activated both in response to in
vivo exercise and ex vivo contraction. AMPK is therefore believed to be an ... Cited by 47 - Related articles - BL Direct - All 9 versions
- ►utah.edu [PDF] JE Lindsley, J Rutter - Comparative Biochemistry and Physiology, Part B, 2004 - Elsevier All organisms appear to have the ability to sense the available nutrients on a
moment-to-moment basis and adjust flux through metabolic pathways and networks
accordingly. It has long been appreciated in single-celled organisms that ... Cited by 44 - Related articles - All 5 versions
- ►physiology.org K Hojlund, KJ Mustard, P Staehr, DG Hardie, … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Acute or chronic activation of AMP-activated protein kinase (AMPK) increases
insulin sensitivity. Conversely, reduced expression and/or function of AMPK
might play a role in insulin resistance in type 2 diabetes. Thus protein ... Cited by 37 - Related articles - BL Direct - All 4 versions
