- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen, DL … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure. Apoptosis is probably
the main form of β-cell death in both forms of the disease. It has been suggested that the
mechanisms leading to nutrient- and ... Cited by 174 - Related articles - BL Direct - All 10 versions
- ►oxfordjournals.org J Caprioli, F Castelletti, S Bucchioni, P … - Human molecular …, 2003 - Oxford Univ Press Mutations in complement factor H (HF1) gene have been reported in non-Shiga toxin-associated and
diarrhoea-negative haemolytic uraemic syndrome (D - HUS). We analysed the complete HF1 in 101
patients with HUS, in 32 with ... Cited by 116 - Related articles - BL Direct - All 7 versions
B Kutlu, AK Cardozo, MI Darville, M Kruhoffer … - DIABETES-NEW …, 2003 - Am Diabetes Assoc Locally released cytokines contribute to -cell dysfunc- tion and apoptosis in type 1 diabetes. In
vitro exposure of insulin-producing INS-1E cells to the cytokines inter- leukin (IL)-1 interferon
(IFN)- leads to a signifi- cant ... Cited by 91 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in the islets of
Langerhans involving activation of apoptosis and necrosis and the production of proinflammatory
molecules that negatively influence ... Cited by 72 - Related articles - BL Direct - All 4 versions
VB Djordjevi - International review of cytology, 2004 - Elsevier In aerobic cells, free radicals are constantly produced mostly as reactive oxygen species. Once
produced, free radicals are removed by antioxidant defenses including enzyme catalase, glutathione
peroxidase, and superoxide ... Cited by 73 - Related articles - BL Direct - All 6 versions
S Bregenholt, A Møldrup, N Blume, AE Karlsen, BN … - … and Biophysical Research …, 2005 - Elsevier We here show that GLP-1 and the long-acting GLP-1 analogue, liraglutide, interfere with
diabetes-associated apoptotic processes in the β-cell. Studies using primary neonatal rat islets
showed that native GLP-1 and ... Cited by 71 - Related articles - All 4 versions
SW Ballinger - Free Radical Biology and Medicine, 2005 - Elsevier Whereas the pathogenesis of atherosclerosis has been intensively studied and described, the
underlying events that initiate cardiovascular disease are not yet fully understood. A substantial
number of studies suggest that ... Cited by 63 - Related articles - All 6 versions
- ►physiology.org DX Zhang, DD Gutterman - American Journal of Physiology- Heart …, 2007 - Am Physiological Soc Once thought of as toxic by-products of cellular metabolism, reactive oxygen species (ROS) have been
implicated in a large variety of cell-signaling processes. Several enzymatic systems contribute to
ROS production in vascular ... Cited by 60 - Related articles - BL Direct - All 5 versions
R Brigelius-Flohé, A Banning, M Kny, GF Böl - Archives of Biochemistry and …, 2004 - Elsevier There is increasing evidence that reactive oxygen species (ROS) are mediators in growth factor and
cytokine signaling pathways. Mechanisms by which ROS can interfere with signaling cascades may
include regulation of protein ... Cited by 56 - Related articles - All 3 versions
G Hughes, MP Murphy, EC Ledgerwood - Biochemical Journal, 2005 - pubmedcentral.nih.gov ROS (reactive oxygen species) from mitochondrial and non-mitochondrial sources have been implicated
in TNFα (tumour necrosis factor α)-mediated signalling. In the present study, a new class of
specific mitochondria-targeted ... Cited by 54 - Related articles - All 7 versions
