BB Lowell, GI Shulman - Science, 2005 - sciencemag.org Type 2 diabetes is the most common metabolic disease in the world. In the United States, it is
the leading cause of blindness, end-stage renal disease, and nontraumatic loss of limb, with
associated health care costs estimated to exceed $130 billion per year (1). Of even ... Cited by 510 - Related articles - All 6 versions
- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen, DL … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure. Apoptosis is probably
the main form of β-cell death in both forms of the disease. It has been suggested that the mechanisms
leading to nutrient- and cytokine-induced β-cell death in type 2 and type 1 diabetes, ... Cited by 174 - Related articles - BL Direct - All 10 versions
- ►cell.com P Steneberg, N Rubins, R Bartoov-Shifman, MD Walker … - Cell metabolism, 2005 - Elsevier Obesity is typically associated with elevated levels of free fatty acids (FFAs) and is linked to glucose
intolerance and type 2 diabetes. FFAs exert divergent effects on insulin secretion from β
cells: acute exposure to FFAs stimulates insulin secretion, whereas chronic exposure ... Cited by 113 - Related articles - All 11 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2 diabetics. It was found
that islet function was about 50% of normal at the time of diagnosis, and a reduction in ß-cell
mass of about 60% was shown at necropsy. The reduction of ß-cell mass is attributable to ... Cited by 105 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org R Belfort, L Mandarino, S Kashyap, K Wirfel, T … - Diabetes, 2005 - Am Diabetes Assoc The dose-response relationship between elevated plasma free fatty acid (FFA) levels and impaired
insulin-mediated glucose disposal and insulin signaling was examined in 21 lean, healthy, normal
glucose-tolerant subjects. Following a 4-h saline or Liposyn infusion at 30 (n = 9), 60 (n = ... Cited by 88 - Related articles - All 5 versions
DK Richardson, S Kashyap, M Bajaj, K Cusi, SJ … - Journal of Biological …, 2005 - ASBMB Page 1. Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and
Increases Expression of Extracellular Matrix Genes in Human Skeletal Muscle Dawn K.
Richardson 1* , Sangeeta Kashyap 1* , Mandeep Bajaj 1 , Kenneth Cusi 1 , Steven J. ... Cited by 82 - Related articles - All 9 versions
- ►ecmaj.ca AYY Cheng, IG Fantus - Canadian Medical Association Journal, 2005 - ecmaj.ca DIABETES MELLITUS IS A CHRONIC DISEASE that is growing in prevalence worldwide. Pharmacologic
therapy is often necessary to achieve optimal glycemic control in the management of
diabetes. Orally administered antihyperglycemic agents (OHAs) can be used either alone ... Cited by 71 - Related articles - All 16 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that are proposed
to play a role in all forms of type 2 diabetes. The underlying concept is that once the primary pathogenesis
of diabetes is established, probably involving both genetic and environmental forces, ... Cited by 71 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org G Boden, M Laakso - Diabetes Care, 2004 - Am Diabetes Assoc Historically, type 2 diabetes was considered to revolve around a glucose-insulin axis. The foundations
for this thinking were probably laid down by two momentous discoveries in diabetes
research. According to popular legend, Oskar Minkowski noticed that urine from his ... Cited by 58 - Related articles - All 5 versions
H Walter, G Lubben - Drugs, 2005 - ingentaconnect.com Worsening glycaemic control in type 2 diabetes mellitus relates to a decline in Abstract β-cell
function, associated with impaired negative feedback regulation of insulin release. Insulin
resistance, the 'traditional' cornerstone defect of type 2 diabetes, leads to an array of ... Cited by 59 - Related articles - All 5 versions
