- ►diabetesjournals.org CC Wang, ML Goalstone, B Draznin - Diabetes, 2004 - Am Diabetes Assoc Insulin resistance is concomitant with type 2 diabetes, obesity, hypertension,
and other features of the metabolic syndrome. Because insulin resistance is
associated with cardiovascular disease, both scientists and physicians have ... Cited by 109 - Related articles - BL Direct - All 8 versions
- ►endojournals.org J Nigro, N Osman, AM Dart, PJ Little - Endocrine reviews, 2006 - Endocrine Soc In metabolic tissues, insulin signaling via the phosphatidylinositol-3-kinase
pathway leads to glucose uptake so that in insulin resistance a state of
hyperglycemia occurs; other factors such as dyslipidemia and hypertension ... Cited by 100 - Related articles - BL Direct - All 5 versions
- ►cell.com ZP Liu, Z Wang, H Yanagisawa, EN Olson - Developmental Cell, 2005 - Elsevier Smooth muscle cells (SMCs) modulate their phenotype between proliferative and
differentiated states in response to physiological and pathological cues.
Insulin-like growth factor-I stimulates differentiation of SMCs by ... Cited by 62 - Related articles - All 14 versions
- ►shouxi.net B Draznin - Diabetes, 2006 - Am Diabetes Assoc Initial attempts to unravel the molecular mechanism of insulin resistance have
strongly suggested that a defect responsible for insulin resistance in the
majority of patients lies at the postreceptor level of insulin signaling. ... Cited by 51 - Related articles - BL Direct - All 5 versions
D LeRoith, V Fonseca, A Vinik - Diabetes/Metabolism Reviews - interscience.wiley.com Large-scale clinical trials have demonstrated that metabolic control achieved
early in the course of diabetes substantially reduces development and
progression of diabetes and the associated microvascular complications. ... Cited by 46 - Related articles - All 3 versions
- ►shouxi.net MA Potenza, FL Marasciulo, M Tarquinio, MJ … - Diabetes, 2006 - Am Diabetes Assoc Spontaneously hypertensive rats (SHRs) exhibit endothelial dysfunction and
insulin resistance. Reciprocal relationships between endothelial dysfunction and
insulin resistance may contribute to hypertension by causing imbalanced ... Cited by 40 - Related articles - BL Direct - All 6 versions
S Bansilal, ME Farkouh, V Fuster - The American Journal of Cardiology, 2007 - Elsevier Insulin resistance (IR) is the underlying defect in >90% of patients with type 2
diabetes mellitus and the major pathologic mechanism for the associated
susceptibility to premature cardiovascular disease (CVD). The progression ... Cited by 33 - Related articles - All 33 versions
- ►shouxi.net EB Okon, AWY Chung, P Rauniyar, E Padilla, … - Diabetes, 2005 - Am Diabetes Assoc Diabetes is associated with a perturbation of signaling pathways in vascular
tissue, which causes vasomotor dysfunction such as hypertension and accelerated
atherosclerosis. In the present study, the mechanisms of vasomotor ... Cited by 33 - Related articles - BL Direct - All 5 versions
H Huang, DJ Tindall - Future Oncol., 2006 - Future Medicine Forkhead box O-class (FOXO) transcription factors, including FOXO1, FOXO3a and
FOXO4, function as tumor-suppressor proteins by inhibiting cell proliferation,
promoting apoptotic cell death and protecting cells from DNA damage and ... Cited by 32 - Related articles - BL Direct - All 4 versions
GD Frank, S Eguchi, ED Motley - Antioxidants & Redox Signaling, 2005 - liebertonline.com T HE PREVALENCE OF DIABETES and insulin resistance is fast approaching epidemic
levels throughout the Western world. Insulin, the primary metabolic regulatory
hormone that controls glucose uptake by cells, is the major player in di- ... Cited by 26 - Related articles - BL Direct - All 3 versions
