- ►jbc.org Y Gorin, K Block, J Hernandez, B Bhandari, B … - Journal of Biological …, 2005 - ASBMB Renal hypertrophy and extracellular matrix accumulation are early features of diabetic
nephropathy. We investigated the role of the NAD(P)H oxidase Nox4 in generation of reactive
oxygen species (ROS), hypertrophy, and fibronectin expression in a rat model of type 1 ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►pnas.org T Yu, JL Robotham, Y Yoon - Proceedings of the National …, 2006 - National Acad Sciences Increased production of mitochondrial reactive oxygen species (ROS) by hyperglycemia is recognized
as a major cause of the clinical complications associated with diabetes and obesity
[Brownlee, M. (2001) Nature 414, 813–820]. We observed that dynamic changes in ... Cited by 91 - Related articles - BL Direct - All 9 versions
D Kukidome, T Nishikawa, K Sonoda, K Imoto, K … - Diabetes, 2006 - Am Diabetes Assoc We previously proposed that the production of hyperglycemia-induced mitochondrial reactive
oxygen species (mtROS) is a key event in the development of diabetes complications. The association
between the pathogenesis of diabetes and its complications and mitochondrial ... Cited by 83 - Related articles - BL Direct - All 6 versions
T Nishikawa, E Araki - Antioxidants & Redox Signaling, 2007 - liebertonline.com T HE MITOCHONDRION is believed to be an organelle derived from a genetic component(s)
of microorganisms, and thus its replication, transcription, and translation system has been developed
on its own basis, although several nuclear genome–encoded proteins are also essential ... Cited by 51 - Related articles - BL Direct - All 4 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad complications
related to the disease. One of the most explored hypotheses to explain the onset of complications
is a hyperglycemia-induced increase in oxidative stress. Reactive oxygen species (ROS) ... Cited by 53 - Related articles - BL Direct - All 6 versions
- ►fasebj.org CJ DOUGHERTY, LA KUBASIAK, DP FRAZIER, H LI, … - The FASEB Journal, 2004 - FASEB C-Jun N-terminal kinase (JNK) is part of the mitogen-activated protein kinase (MAPK) family
of signaling pathways that are induced in response to extracellular stimuli. JNK is primarily a
stress-response pathway and can be activated by proinflammatory cytokines and growth ... Cited by 50 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org Z Bagi, N Erdei, A Toth, W Li, TH Hintze, A … - … , and vascular biology, 2005 - Am Heart Assoc Methods and Results— In mice with T2-DM (C57BL/KsJ-db – /db – ), systolic and mean arterial
pressures measured by the tail cuff method were significantly elevated compared with those
of control (db + /db – ) animals (db/db, 146±5 and 106±2 mm Hg versus control, 133±4 ... Cited by 50 - Related articles - All 9 versions
L Piconi, L Quagliaro, R Assaloni, R Da Ros, … - Diabetes/Metabolism … - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 44 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org ZG Xu, L Lanting, ND Vaziri, Z Li, L Sepassi, B … - Circulation, 2005 - Am Heart Assoc Background— Severe obesity can result in proteinuria and progressive glomerulosclerosis in
humans and experimental animals. The associated renal disease is ameliorated by weight reduction
and/or blockade of the renin-angiotensin system. Various growth factors, cytokines, and ... Cited by 41 - Related articles - All 9 versions
- ►nih.gov G Waris, A Siddiqui - Journal of virology, 2005 - Am Soc Microbiol Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, which can lead to
the development of liver cirrhosis and hepatocellular carcinoma. Recently, the activation of
cyclooxygenase-2 (Cox-2) has been implicated in the HCV-associated hepatocellular ... Cited by 42 - Related articles - BL Direct - All 9 versions
