- ►diabetesjournals.org Y Yamamoto, Y Maeshima, H Kitayama, S … - Diabetes, 2004 - Am Diabetes Assoc In the early stage of diabetic nephropathy (one of the major microvascular
complications of diabetes) glomerular hyperfiltration and hypertrophy are
observed. It is clinically important to regulate glomerular hypertrophy for ... Cited by 84 - Related articles - BL Direct - All 6 versions
- ►asnjournals.org FY Chow, DJ Nikolic-Paterson, E Ozols, RC … - Journal of the American Society of Nephrology, 2005 - Am Soc Nephrol Diabetic nephropathy is a leading cause of end-stage renal failure and is a
growing concern given the increasing incidence of type 2 diabetes. Diabetic
nephropathy is associated with progressive kidney macrophage accumulation ... Cited by 67 - Related articles - All 7 versions
- ►asnjournals.org E Galkina, K Ley - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol Different types of activated leukocytes play a crucial role in the pathogenesis
of most kidney diseases from acute to chronic stages; however, diabetic
nephropathy was not considered an inflammatory disease in the past. This ... Cited by 68 - Related articles - BL Direct - All 5 versions
- ►asnjournals.org G Gruden, G Setti, A Hayward, D Sugden, S … - Journal of the American Society of Nephrology, 2005 - Am Soc Nephrol Hemodynamic abnormalities are important in the pathogenesis of the glomerular
damage in diabetes. Glomerular macrophage infiltration driven by the chemokine
monocyte chemoattractant protein-1 (MCP-1) is an early event in diabetic ... Cited by 54 - Related articles - All 6 versions
- ►asnjournals.org W Wang, XR Huang, AG Li, F Liu, JH Li, LD … - Journal of the American Society of Nephrology, 2005 - Am Soc Nephrol TGF- has been shown to play a critical role in anti-inflammation; however, the
signaling mechanisms of TGF- in anti-inflammatory response remains largely
unclear. This study reported that mice that overexpress latent TGF- 1 on ... Cited by 53 - Related articles - All 5 versions
- ►asnjournals.org JF Navarro-Gonzalez, C Mora-Fernandez - Journal of the American Society of Nephrology, 2008 - Am Soc Nephrol Cytokines act as pleiotropic polypeptides regulating inflammatory and immune
responses through actions on cells. They provide important signals in the
pathophysiology of a range of diseases, including diabetes mellitus. ... Cited by 46 - Related articles - All 5 versions
- ►physiology.org [PDF] S Ohga, K Shikata, K Yozai, S Okada, D … - American Journal of Physiology- Renal Physiology, 2006 - Am Physiological Soc Page 1. Ohga et al., Page 1 Original Article Thiazolidinedione ameliorates
renal injury in experimental diabetic rats through anti ... Cited by 39 - Related articles - BL Direct - All 8 versions
- ►asnjournals.org K Yozai, K Shikata, M Sasaki, A Tone, S … - Journal of the American Society of Nephrology, 2005 - Am Soc Nephrol Recent studies suggested the involvement of inflammatory processes in the
pathogenesis of diabetic nephropathy. Methotrexate (MTX), a folic acid
antagonist, is widely used for the treatment of inflammatory diseases. ... Cited by 34 - Related articles - BL Direct - All 5 versions
KG Ewens, RA George, K Sharma, FN … - Diabetes, 2005 - Am Diabetes Assoc Several lines of evidence, including familial aggregation, suggest that allelic
variation contributes to risk of diabetic nephropathy. To assess the evidence
for specific susceptibility genes, we used the transmission/disequilibrium ... Cited by 34 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org A Nakamura, K Shikata, M Hiramatsu, T … - Diabetes Care, 2005 - Am Diabetes Assoc RESULTS—Serum and urinary IL-18 levels were significantly elevated in patients
with type 2 diabetes as compared with control subjects (serum IL-18 179 ± 62
vs. 121 ± 55 pg/ml, P < 0.001; urinary IL-18 97 ± 159 vs. 47 ± 54 pg/ml, ... Cited by 31 - Related articles - BL Direct - All 5 versions
