- ►pnas.org GGM Pinkse, OHM Tysma, CAM Bergen, MGD … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an
important target of the autoimmune response associated with β cell destruction.
The mechanism of destruction is still unknown. Here, we provide evidence ... Cited by 87 - Related articles - BL Direct - All 10 versions
SM Lieberman, TP DiLorenzo - Tissue Antigens, 2003 - interscience.wiley.com Abstract: Type 1 diabetes (T1D) is an organ-specific autoimmune disease in which
the insulin-producing β cells in the pancreatic islets are selectively
eliminated. T cells specific for β-cell antigens are the mediators of this ... Cited by 60 - Related articles - BL Direct - All 5 versions
- ►nih.gov A Toma, S Haddouk, JP Briand, L Camoin, H … - Proceedings of the National Academy of Sciences of …, 2005 - National Acad Sciences Proinsulin is a key autoantigen in type 1 diabetes. Evidence in the mouse has
underscored the importance of the insulin B chain region in autoimmunity to
pancreatic beta cells. In man, a majority of proteasome cleavage sites are ... Cited by 56 - Related articles - BL Direct - All 8 versions
TP Di Lorenzo, M Peakman, BO Roep - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov T cell epitopes represent the molecular code words through which the adaptive
immune system communicates. In the context of a T cell-mediated autoimmune
disease such as type 1 diabetes, CD4 and CD8 T cell recognition of islet ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org Q Ouyang, NE Standifer, H Qin, P Gottlieb, … - Diabetes, 2006 - Am Diabetes Assoc Type 1 diabetes results from the autoimmune destruction of insulin-producing
pancreatic β-cells by cytotoxic T-lymphocytes (CTLs). In humans, few β-cell
epitopes have been reported, thereby limiting the study of ... Cited by 36 - Related articles - BL Direct - All 4 versions
TP DiLorenzo, DV Serreze - Immunol. Rev, 2005 - interscience.wiley.com Summary: Type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice
is a T-cell-mediated autoimmune disease in which the insulin-producing
pancreatic islet β-cells are selectively eliminated. As a result, glucose ... Cited by 35 - Related articles - All 7 versions
- ►jimmunol.org T Takaki, MP Marron, CE Mathews, ST … - The Journal of Immunology, 2006 - Am Assoc Immnol In both humans and NOD mice, particular MHC genes are primary contributors to
development of the autoreactive CD4 + and CD8 + T cell responses against
pancreatic cells that cause type 1 diabetes (T1D). Association studies have ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org NE Standifer, Q Ouyang, C Panagiotopoulos, … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-lymphocytes (CTLs) are considered to be essential for β-cell
destruction in type 1 diabetes. However, few islet-associated peptides have been
demonstrated to activate autoreactive CTLs from type 1 diabetic subjects. ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org J Yang, NA Danke, DA Berger, S … - The Journal of Immunology, 2006 - Am Assoc Immnol Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) is
recognized as a major autoantigen for autoimmune type 1 diabetes (T1D) in the
NOD mouse model. This study was undertaken to examine CD4 + T cell ... Cited by 25 - Related articles - BL Direct - All 8 versions
K Haskins - Advances in immunology, 2005 - Elsevier T-cell clones that can efficiently transfer diabetes to prediabetic nonobese
diabetic (NOD) mice provide a powerful approach to dissecting the autoimmune
disease process and for investigating immunoregulation. Diabetogenic T-cell ... Cited by 19 - Related articles - BL Direct - All 4 versions
