AW Xu, CB Kaelin, GJ Morton, K Ogimoto, K … - PLoS …, 2005 - biology.plosjournals.org Normal aging in humans and rodents is accompanied by a progressive increase in
adiposity. To investigate the role of hypothalamic neuronal circuits in this process, we used a
Cre-lox strategy to create mice with specific and progressive degeneration of ... Cited by 32 - Related articles - Cached - BL Direct - All 11 versions
AP Coll, BG Challis, M López, S Piper, GSH Yeo, SO' … - Diabetes, 2005 - Am Diabetes Assoc Congenital lack of proopiomelanocortin (POMC) causes obesity and glucocorticoid
deficiency. The responses of Pomc −/− and wild-type mice to the administration of corticosterone
were compared. In study 1, mice were given corticosterone-supplemented water (CORT) ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►cnfindpark.cn G Cai, SA Cole, RA Bastarrachea-Sosa, JW … - American Journal of …, 2004 - ajcn.cnfindpark.cn 2 Supported by National Heart, Lung, and Blood Institute grant P01 HL45522. ...
Background: Obesity is generally accompanied by increased food intake. ... Objective: We sought
to identify the genes influencing variation in dietary macronutrient intakes in Mexican ... Cited by 26 - Related articles - BL Direct - All 6 versions
G Li, Y Zhang, JT Wilsey, PJ Scarpace - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Age-related obesity is asso- ciated with impaired hypothalamic
pro-opiomelanocortin (Pomc) gene expression. We assessed whether overproduc- tion of POMC
in the hypothalamus ameliorates age-related obesity in rats. Methods: Recombinant ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►endojournals.org E Savontaus, TL Breen, A Kim, LM Yang, SC Chua Jr, … - Endocrinology, 2004 - Endocrine Soc The proopiomelanocortin-derived peptide, -MSH, inhibits feeding via melanocortin receptors
in the hypothalamus and genetic defects inactivating the melanocortin system have been shown
to lead to obesity in experimental animals and humans. To determine whether long-term ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►nih.gov L Zhou, GM Sutton, JJ Rochford, RK Semple, DD Lam, … - Cell metabolism, 2007 - Elsevier The burden of type 2 diabetes and its associated premature morbidity and mortality is rapidly
growing, and the need for novel efficacious treatments is pressing. We report here that serotonin
2C receptor (5-HT 2C R) agonists, typically investigated for their anorectic properties, ... Cited by 19 - Related articles - All 11 versions
- ►nih.gov D Ren, Y Zhou, D Morris, M Li, Z Li, L … - Journal of Clinical …, 2007 - Am Soc Clin Investig SH2B1 (previously named SH2-B), a cytoplasmic adaptor protein, binds via its Src homology
2 (SH2) domain to a variety of protein tyrosine kinases, including JAK2 and the insulin
receptor. SH2B1-deficient mice are obese and diabetic. Here we demonstrated that ... Cited by 19 - Related articles - BL Direct - All 8 versions
- ►endocrinology-journals.org H Shimizu, K Inoue, M Mori - Journal of Endocrinology, 2007 - Soc Endocrinology The brain hypothalamus coordinates extra-hypothalamic regions to maintain energy homeostasis
through the regulation of food intake and energy expenditure. A number of anorexigenic and
orexigenic molecules in the hypothalamic nuclei participate in the control of energy ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►physiology.org JE McMinn, SM Liu, H Liu, I Dragatsis, P … - American Journal of …, 2005 - Am Physiological Soc Leptin signaling in the brain regulates energy intake and expenditure. To test the degree of functional
neuronal leptin signaling required for the maintenance of body composition, fertility, and cold
tolerance, transgenic mice expressing Cre in neurons (CaMKII -Cre) were crossed to ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►tno.co.jp [PDF] AC Heijboer, AM van den Hoek, H Pijl, PJ Voshol, LM … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: The present study was con- ducted to evaluate the effects of central
administration of melanotan II (MTII), a melanocortin-3/4 receptor agonist, on hepatic and
whole-body insulin sensitivity, independent of food intake and body weight. Methods: ... Cited by 13 - Related articles - BL Direct - All 4 versions
