- ►jimmunol.org MMW Chong, Y Chen, R Darwiche, NL Dudek, … - The Journal of Immunology, 2004 - Am Assoc Immnol In type 1 diabetes, cytokine action on cells potentially contributes to cell
destruction by direct cytotoxicity, inducing Fas expression, and up-regulating
class I MHC and chemokine expression to increase immune recognition. To ... Cited by 37 - Related articles - BL Direct - All 4 versions
CA Gysemans, L Ladrière, H Callewaert, J … - Diabetes, 2005 - Am Diabetes Assoc The main focus in studies on the pathogenesis of autoimmune type 1 diabetes has
been on the role of the immune system, with much less attention directed to the
target of the immune assault, namely the insulin-secreting β-cells. ... Cited by 33 - Related articles - BL Direct - All 6 versions
M Li, D Guo, CM Isales, DL Eizirik, M … - Journal of Molecular Medicine, 2005 - Springer Page 1. J Mol Med (2005) 83: 504–513 DOI 10.1007/s00109-005-0645-5 REVIEW Manyu
Li . Dehuang Guo . Carlos M. Isales . Decio L. Eizirik . Mark Atkinson . ... Cited by 32 - Related articles - BL Direct - All 3 versions
AE Karlsen, PE Heding, H Frobøse, SG Rønn, M … - Diabetologia, 2004 - Springer Aims/hypothesis. The proinflammatory cytokine IL-1β induces apoptosis in
pancreatic beta cells via path- ways dependent on nuclear factor-κB (NF-κB),
mito- gen-activated protein kinase, and protein kinase C. We recently ... Cited by 25 - Related articles - All 3 versions
GM Davey, WR Heath, R Starr - Tissue Antigens, 2006 - interscience.wiley.com Suppressor of cytokine signalling-1 (SOCS1), as the name implies, is a protein
that functions as a negative regulator of cytokine signalling. Initially
characterized for its ability to inhibit JAK phosphorylation and function, ... Cited by 28 - Related articles - All 5 versions
T Matsuda, K Ferreri, I Todorov, Y Kuroda, CV … - Endocrinology, 2005 - Endocrine Soc Silymarin is a polyphenolic flavonoid that has a strong antioxidant activity and
exhibits anticarcinogenic, antiinflammatory, and cytoprotective effects.
Although its hepatoprotective effect has been well documented, the effect ... Cited by 24 - Related articles - All 5 versions
- ►oxfordjournals.org MD McKenzie, NL Dudek, L Mariana, MMW … - International immunology, 2006 - Jpn Soc Immunol Direct interaction between auto-reactive CTL and specific peptide–MHC class I
complexes on pancreatic beta cells is critical in mediating beta cell
destruction in type I diabetes. We used mice with genetic modifications in ... Cited by 20 - Related articles - All 4 versions
V Yechoor, L Chan - Gene therapy, 2005 - journals2005.pasteur.ac.ir Page 1. Gene Therapy Volume 12, Issue 2 (January 2005) Gene Therapy Progress and
Prospects: Gene therapy for diabetes mellitus V Yechoor and L Chan ... Cited by 16 - Related articles - All 6 versions
SG Rønn, N Billestrup, T Mandrup-Poulsen - Diabetes, 2007 - Am Diabetes Assoc The pathogenesis of type 1 diabetes is not clearly understood, but it is
generally accepted that type 1 diabetes is an immune-mediated disease caused by
inflammation in the islets of Langerhans. Infiltrating macrophages release ... Cited by 15 - Related articles - BL Direct - All 4 versions
JF Jasmin, I Mercier, F Sotgia, MP Lisanti - Trends in Endocrinology & Metabolism, 2006 - Elsevier Cytokines are secreted proteins that are implicated in numerous cellular
processes, such as immune function, inflammation, cell proliferation and
differentiation [1]. The binding of cytokines to their cell-surface ... Cited by 13 - Related articles - All 5 versions
