- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen, DL … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure. Apoptosis is probably
the main form of β-cell death in both forms of the disease. It has been suggested that the mechanisms
leading to nutrient- and cytokine-induced β-cell death in type 2 and type 1 diabetes, ... Cited by 174 - Related articles - BL Direct - All 10 versions
- ►endojournals.org I Kharroubi, L Ladriere, AK Cardozo, Z Dogusan, M … - Endocrinology, 2004 - Endocrine Soc Apoptosis is probably the main form of ß-cell death in both type 1 diabetes mellitus (T1DM) and
T2DM. In T1DM, cytokines contribute to ß-cell destruction through nuclear factor- B (NF- B)
activation. Previous studies suggested that in T2DM high glucose and free fatty acids ... Cited by 136 - Related articles - BL Direct - All 3 versions
I Kharroubi, J Rasschaert, DL Eizirik, M Cnop - Biochemical and Biophysical …, 2003 - Elsevier Pancreatic β cell dysfunction is an early and crucial pathogenic factor in the development of type
2 diabetes. Free fatty acids (FFA) and adipokines released from adipose tissues lead to both
the development of insulin resistance and β cell dysfunction. Adiponectin is a novel ... Cited by 132 - Related articles - All 6 versions
AK Cardozo, F Ortis, J Storling, YM Feng, J Rasschaert, … - Diabetes, 2005 - Am Diabetes Assoc Cytokines and free radicals are mediators of β-cell death in type 1 diabetes. Under in vitro
conditions, interleukin-1β (IL-1β) + γ-interferon (IFN-γ) induce nitric oxide (NO) production and
apoptosis in rodent and human pancreatic β-cells. We have previously shown, by ... Cited by 102 - Related articles - All 8 versions
- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►nih.gov MG Hartman, D Lu, ML Kim, GJ Kociba, T … - Molecular and Cellular …, 2004 - Am Soc Microbiol Activating transcription factor 3 (ATF3) is a stress-inducible gene and encodes a member of the
ATF/CREB family of transcription factors. However, the physiological significance of ATF3 induction
by stress signals is not clear. In this report, we describe several lines of evidence ... Cited by 85 - Related articles - BL Direct - All 11 versions
L Li, W El-Kholy, CJ Rhodes, PL Brubaker - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: The gut hormone glucagon- like peptide-1 (GLP-1) decreases beta
cell apoptosis in a protein kinase B (PKB)-dependent fashion, and increases islet cell mass and
function in vivo. In contrast, cytokines induce beta cell apoptosis, leading to decreased ... Cited by 68 - Related articles - BL Direct - All 3 versions
JC Schisler, PB Jensen, DG Taylor, TC … - Proceedings of the …, 2005 - National Acad Sciences We have previously described rat insulinoma INS-1-derived cell lines with robust or poor
glucose-stimulated insulin secretion (GSIS). In the current study, we have further resolved these
lines into three classes: class 1, glucose-unresponsive/glucagon-expressing; class 2, ... Cited by 55 - Related articles - All 11 versions
- ►diabetesjournals.org JR Bain, JC Schisler, K Takeuchi, CB Newgard, TC … - Diabetes, 2004 - Am Diabetes Assoc Silencing gene expression by RNA interference (RNAi) can provide insight into gene function
but requires efficient delivery of small interfering RNAs (siRNAs) into cells. Introduction of exogenous
nucleic acids can be especially difficult in cultured pancreatic islets. This article describes ... Cited by 52 - Related articles - BL Direct - All 5 versions
- ►daegu.ac.kr [PDF] J Rasschaert, D Liu, B Kutlu, AK Cardozo, M Kruhøffer, … - Diabetologia, 2003 - Springer Aims/hypothesis. Viral infections and local production of IFN-γ might contribute to beta-cell
dysfunction/ death in Type 1 Diabetes. Double stranded RNA (dsRNA) accumulates in the cytosol
of viral-infected cells, and exposure of purified rat beta cells to dsRNA (tested in the form ... Cited by 41 - Related articles - BL Direct - All 4 versions
