- ►diabetesjournals.org EA Ryan, BW Paty, PA Senior, D Bigam, E Alfadhli, NM … - Diabetes, 2005 - Am Diabetes Assoc Islet transplantation can restore endogenous β-cell function to subjects with type 1 diabetes.
Sixty-five patients received an islet transplant in Edmonton as of 1 November 2004. Their mean age
was 42.9 ± 1.2 years, their mean ... Cited by 532 - Related articles - All 10 versions
- ►nih.gov M Trucco - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Type 1 diabetes is the result of an autoimmune attack against the insulin-producing β cells of the
endocrine pancreas. Current treatment for patients with type 1 diabetes typically involves a
rigorous and invasive regimen of ... Cited by 69 - Related articles - All 9 versions
J Shapiro… - Transplantation, 2005 - journals.lww.com We gratefully acknowledge ongoing support from a Clinical Center for Islet Transplantation Grant
from the Juvenile Diabetes Research Foundation, Capital Health and the Province Wide Services of the
Government of Alberta, the Roberts ... Cited by 68 - Related articles - BL Direct - All 4 versions
- ►endojournals.org JL Larsen - Endocrine reviews, 2004 - Endocrine Soc Pancreas transplantation continues to evolve as a strategy in the management of diabetes mellitus.
The first combined pancreas-kidney transplant was reported in 1967, but pancreas transplant now
represents a number of procedures, ... Cited by 59 - Related articles - All 6 versions
- ►diabetesjournals.org MR Rickels, MH Schutta, JF Markmann, CF Barker, A … - Diabetes, 2005 - Am Diabetes Assoc Islet transplantation can provide metabolic stability for patients with type 1 diabetes; however,
more than one donor pancreas is usually required to achieve insulin independence. To evaluate
possible mechanistic defects ... Cited by 55 - Related articles - All 6 versions
- ►diabetesjournals.org N Zhang, D Su, S Qu, T Tse, R Bottino, AN … - Diabetes, 2006 - Am Diabetes Assoc Successful islet transplantation depends on the infusion of sufficiently large quantities of islets,
but only a fraction of transplanted islets can survive and become engrafted, and yet the underlying
mechanism remains unclear. In this ... Cited by 42 - Related articles - BL Direct - All 7 versions
SA Nanji, AM Shapiro - Diabetes Obesity and Metabolism, 2006 - interscience.wiley.com With recent advances in methods of islet isolation and the introduction of more potent and less
diabetogenic immunosuppressive therapies, islet transplantation has progressed from research to
clinical reality. Presently, ... Cited by 38 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org H Chen, X Li, PN Epstein - Diabetes, 2005 - Am Diabetes Assoc Reactive oxygen species (ROS) and nitric oxide (NO) are proposed mediators of cytokine-induced
β-cell destruction in type 1 diabetes. We produced transgenic mice with increased β-cell
expression of manganese superoxide ... Cited by 34 - Related articles - All 6 versions
- ►diabetesjournals.org H Hui, N Khoury, X Zhao, L Balkir, ED'Amico, A Bullotta, … - Diabetes, 2005 - Am Diabetes Assoc Immunosuppressive drugs are routinely used to provide tolerance after whole pancreas and islet cell
transplantations. While they are essential in inhibiting graft rejection, little is known about
their effect on islet function and ... Cited by 33 - Related articles - All 5 versions
- ►cell.com N Luong, CR Davies, RJ Wessells, SM Graham, MT … - Cell metabolism, 2006 - Elsevier Reducing insulin/IGF signaling allows for organismal survival during periods of inhospitable
conditions by regulating the diapause state, whereby the organism stockpiles lipids, reduces
fertility, increases stress ... Cited by 32 - Related articles - All 13 versions
