- ►shouxi.net PE Cryer - New England Journal of Medicine, 2004 - content.nejm.org In this article, I discuss the clinical problem of hypoglycemia in diabetes from the perspective
of pathophysiology. First, the syndromes of defective glucose counterregulation and hypoglycemia
without warning symptoms (known as "hypoglycemia unawareness") are described, ... Cited by 156 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org R Wang, X Liu, ST Hentges, AA Dunn-Meynell, BE … - Diabetes, 2004 - Am Diabetes Assoc Glucosensing neurons in the hypothalamic arcuate nucleus (ARC) were studied using electrophysiological
and immunocytochemical techniques in neonatal male Sprague-Dawley rats. We identified
glucose-excited and -inhibited neurons, which increase and decrease, respectively, their ... Cited by 106 - Related articles - BL Direct - All 5 versions
L Kang, VH Routh, EV Kuzhikandathil, LD Gaspers, BE … - Diabetes, 2004 - Am Diabetes Assoc To evaluate potential mechanisms for neuronal glucosensing, fura-2 Ca 2+ imaging and
single-cell RT-PCR were carried out in dissociated ventromedial hypothalamic nucleus
(VMN) neurons. Glucose-excited (GE) neurons increased and glucose-inhibited (GI) ... Cited by 94 - Related articles - BL Direct - All 7 versions
PE Cryer - Diabetes, 2005 - Am Diabetes Assoc Iatrogenic hypoglycemia is a problem for people with diabetes. It causes recurrent morbidity,
and sometimes death, as well as a vicious cycle of recurrent hypoglycemia, precluding maintenance
of euglycemia over a lifetime of diabetes. Improved therapeutic approaches that will ... Cited by 75 - Related articles - BL Direct - All 7 versions
BM King - Physiology & behavior, 2006 - Elsevier Early researchers found that lesions of the ventromedial hypothalamus (VMH) resulted in hyperphagia
and obesity in a variety of species including humans, which led them to designate the VMH as
the brain's “satiety center.” Many researchers later dismissed a role for the VMH in ... Cited by 64 - Related articles - All 5 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►cjb.net D Burdakov, O Gerasimenko, A Verkhratsky - Journal of Neuroscience, 2005 - neuro.cjb.net The physiological signaling mechanisms that link normal variations in body energy status to
the activity of arousal- and metabolism-regulating brain centers are not well understood. The
melanin-concentrating hormone (MCH) and orexin/hypocretin types of neurons of the ... Cited by 50 - Related articles - All 6 versions
- ►diabetesjournals.org L Kang, AA Dunn-Meynell, VH Routh, LD Gaspers, Y … - Diabetes, 2006 - Am Diabetes Assoc To test the hypothesis that glucokinase is a critical regulator of neuronal glucosensing, glucokinase
activity was increased, using a glucokinase activator drug, or decreased, using RNA interference
combined with calcium imaging in freshly dissociated ventromedial hypothalamic nucleus ... Cited by 49 - Related articles - BL Direct - All 7 versions
- ►physiology.org R Wang, C Cruciani-Guglielmacci, S … - Journal of …, 2006 - Am Physiological Soc Pharmacological manipulation of fatty acid metabolism in the hypothalamic arcuate nucleus
(ARC) alters energy balance and glucose homeostasis. Thus, we tested the hypotheses that
distinctive populations of ARC neurons are oleic acid (OA) sensors that exhibit a glucose ... Cited by 35 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org X Fioramonti, A Lorsignol, A Taupignon, L Pénicaud - Diabetes, 2004 - Am Diabetes Assoc Glucose is known to modify electrical activity of neurons in different hypothalamic areas such
as the arcuate nucleus (ARC) or the ventromedian nucleus. In these structures, it has been demonstrated
that glucose-induced excitation of neurons involves ATP-sensitive K + (K ATP ) channel ... Cited by 35 - Related articles - BL Direct - All 4 versions
