MC Arkan, AL Hevener, FR Greten, S Maeda, ZW Li, … - Nature medicine, 2005 - nature.com 1 Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School
of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California
92093, USA. ... 2 Department of Medicine, Division of Endocrinology and Metabolism, ... Cited by 427 - Related articles - All 4 versions
SE Shoelson, L Herrero, A Naaz - Gastroenterology, 2007 - Elsevier Weight gain and obesity are major risk factors for conditions and diseases ranging from insulin
resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of nonalcoholic fatty
liver disease. A chronic, subacute state of inflammation often accompanies the ... Cited by 149 - Related articles - All 23 versions
- ►ajcn.org AS Greenberg, MS Obin - American Journal of Clinical Nutrition, 2006 - Am Soc Nutrition Recent discoveries, notably of the hormones leptin and adiponectin, have revised the notion
that adipocytes are simply a storage depot for body energy. Instead, adipocytes are also endocrine
organs, with multiple metabolic roles in regulating whole-body physiology. Small ... Cited by 141 - Related articles - All 7 versions
AL Carey, GR Steinberg, SL Macaulay, WG Thomas, … - Diabetes, 2006 - Am Diabetes Assoc Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding
the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion increases
glucose disposal without affecting the complete suppression of endogenous glucose ... Cited by 99 - Related articles - BL Direct - All 6 versions
PJ Klover, AH Clementi, RA Mooney - Endocrinology, 2005 - Endocrine Soc Obesity and insulin resistance are considered chronic inflammatory states, in part because circulating
IL-6 is elevated. Exogenous IL-6 can induce hepatic insulin resistance in vitro and in vivo. The
importance of endogenous IL-6, however, to insulin resistance of obesity is unresolved. ... Cited by 93 - Related articles - BL Direct - All 5 versions
C Weigert, K Brodbeck, H Staiger, C Kausch, F … - Journal of Biological …, 2004 - ASBMB Circulating interleukin-6 (IL-6), insulin, and free fatty acid (FFA) concentrations are associated
with impaired insulin action in obese and type 2 diabetic individuals. However, a causal relationship
between elevated plasma FFAs and IL-6 has not been shown. Because skeletal muscle ... Cited by 84 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org MA Febbraio, N Hiscock, M Sacchetti, CP Fischer, BK … - Diabetes, 2004 - Am Diabetes Assoc The mechanisms that mediate the tightly controlled production and clearance of glucose during
muscular work are unclear, and it has been suggested that an unidentified “work factor” exists
that influences the contraction-induced increase in endogenous glucose production ... Cited by 84 - Related articles - BL Direct - All 5 versions
- ►highwire.org H Bruunsgaard - Journal of leukocyte biology, 2005 - jleuk.highwire.org It has been recognized for some time that cardiovascular disease and type 2 diabetes are, to
a major extent, inflammatory disorders associated with an environment characterized by a sedentary
lifestyle together with abundant intakes of calories. Systemic low-level inflammation is ... Cited by 82 - Related articles - BL Direct - All 11 versions
OP Kristiansen, T Mandrup-Poulsen - Diabetes, 2005 - Am Diabetes Assoc Inflammatory mechanisms play a key role in the pathogenesis of type 1 diabetes. Individuals
who progress to type 2 diabetes display features of low-grade inflammation years in advance
of disease onset. This low-grade inflammation has been proposed to be involved in the ... Cited by 72 - Related articles - BL Direct - All 5 versions
