H Kaneto, Y Nakatani, T Miyatsuka, D Kawamori, T … - Nature medicine, 2004 - nature.com The JNK pathway is known to be activated in several tissues in the diabetic state, and is possibly
involved in the development of insulin resistance and suppression of insulin biosynthesis. Here
we show a potential new therapy for diabetes using cell-permeable JNK-inhibitory ... Cited by 167 - Related articles - BL Direct - All 4 versions
Y Kajimoto, H Kaneto - ANNALS-NEW YORK ACADEMY OF …, 2004 - interscience.wiley.com Abstract: Oxidative stress is produced under diabetic conditions and is likely involved in progression
of pancreatic β-cell dysfunction found in diabetes. Possibly caused by low levels of antioxidant
enzyme expressions, pancreatic β-cells are vulnerable to oxidative stress. When β-cell- ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►physoc.org P Newsholme, EP Haber, SM Hirabara, ELO … - The Journal of …, 2007 - Physiological Soc It is now widely accepted, given the current weight of experimental evidence, that reactive oxygen
species (ROS) contribute to cell and tissue dysfunction and damage caused by glucolipotoxicity
in diabetes. The source of ROS in the insulin secreting pancreatic β-cells and in the cells ... Cited by 62 - Related articles - BL Direct - All 8 versions
- ►umich.edu [PDF] JD Malhotra, RJ Kaufman - Antioxidants & Redox Signaling, 2007 - liebertonline.com The endoplasmic reticulum (ER) is a well-orchestrated protein-folding machine composed of
protein chaper- ones, proteins that catalyze protein folding, and sensors that detect the presence
of misfolded or unfolded pro- teins. A sensitive surveillance mechanism exists to prevent ... Cited by 56 - Related articles - All 4 versions
H Kaneto, N Katakami, D Kawamori, T … - Antioxidants & redox …, 2007 - liebertonline.com F AILURE OF PANCREATIC cells is the common characteris- tic of type 1 and type 2
diabetes. Type 1 diabetes melli- tus is induced by destruction of pancreatic cells, which is mediated
by an autoimmune mechanism and the consequent inflammatory process. Various ... Cited by 48 - Related articles - BL Direct - All 4 versions
H Kaneto, T Matsuoka, Y Nakatani, D Kawamori, T … - Journal of Molecular …, 2005 - Springer Page 1. J Mol Med (2005) 83: 429–439 DOI 10.1007/s00109-005-0640-x REVIEW Hideaki Kaneto .
Taka-aki Matsuoka . Yoshihisa Nakatani . Dan Kawamori . Takeshi Miyatsuka . Munehide
Matsuhisa . Yoshimitsu Yamasaki Oxidative stress, ER stress, and the JNK pathway in ... Cited by 47 - Related articles - All 3 versions
- ►jbc.org M Ubeda, JM Rukstalis, JF Habener - Journal of Biological Chemistry, 2006 - ASBMB Type 2 diabetes (T2D) and Alzheimer disease are degenerative diseases that may share common
pathophysiologic mechanisms. Neuronal dysfunction in Alzheimer patients has been linked to
overactivity of the cyclin-dependent kinase 5 (CDK5) and its activator p35. Both of these ... Cited by 48 - Related articles - All 7 versions
DK Hagman, LB Hays, SD Parazzoli, V Poitout - Journal of Biological Chemistry, 2005 - ASBMB Abnormalities in lipid metabolism have been proposed as contributing factors to both defective
insulin secretion from the pancreatic beta cell and peripheral insulin resistance in type 2
diabetes. Previously, we have shown that prolonged exposure of isolated rat islets of ... Cited by 42 - Related articles - BL Direct - All 10 versions
- ►jbc.org D Kawamori, H Kaneto, Y Nakatani, T Matsuoka, M … - Journal of Biological …, 2006 - ASBMB It has been shown that oxidative stress and activation of the c-Jun N-terminal kinase (JNK) pathway
induce the nucleocytoplasmic translocation of the pancreatic transcription factor PDX-1, which
leads to pancreatic -cell dysfunction. In this study, we have shown that the forkhead ... Cited by 43 - Related articles - BL Direct - All 8 versions
H Noguchi, Y Nakai, S Matsumoto, M … - American Journal of …, 2005 - ccmjournal.org Although application of the Edmonton protocol has markedly improved outcomes for pancreatic
islet transplantation, the insulin independence rate after islet transplantation from one donor
pancreas has proven to remain low. During the isolation process and subsequent clinical ... Cited by 37 - Related articles - All 7 versions
