- ►nih.gov S Srinivasan, C Lubrano-Berthelier, C … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig 1 Gladstone Institute of Cardiovascular Disease, 2 Diabetes Center, and 3
Department of Cellular and Molecular Pharmacology, UCSF, San Francisco,
California, USA. ... Address correspondence to: Christian Vaisse, Diabetes ... Cited by 71 - Related articles - BL Direct - All 12 versions
- ►endojournals.org C Lubrano-Berthelier, B Dubern, JM Lacorte, F … - Journal of Clinical Endocrinology & Metabolism, 2006 - Endocrine Soc Context: Heterozygous mutations in the melanocortin-4 receptor (MC4R) gene are
the most common monogenic form of severe obesity in children. There are
conflicting reports regarding the prevalence, nature, and pathogenic ... Cited by 63 - Related articles - BL Direct - All 5 versions
- ►auburn.edu [PDF] YX Tao - Molecular and cellular endocrinology, 2005 - Elsevier The neural melanocortin receptors, melanocortin-3 and -4 receptors (MC3R and
MC4R), have been shown to regulate different aspects of energy homeostasis in
rodents. Human genetic studies showed that mutations in the MC4R gene are ... Cited by 51 - Related articles - All 8 versions
MD Thompson, WMI Burnham, DEC Cole - Critical reviews in clinical laboratory sciences, 2005 - informahealthcare.com Genetic variation in G-protein coupled receptors (GPCRs) is associated with a
wide spectrum of disease phenotypes and predispositions that are of special
significance because they are the targets of therapeutic agents. Each ... Cited by 38 - Related articles - BL Direct - All 12 versions
L Ma, PA Tataranni, C Bogardus, LJ Baier - Diabetes, 2004 - Am Diabetes Assoc Heterozygous coding mutations in the melanocortin 4 receptor gene (MC4R) are the
most common genetic causes of severe human obesity identified to date. To
determine whether MC4R has a role in causing severe obesity in Pima ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org F Stutzmann, V Vatin, S Cauchi, A Morandi, B … - Human Molecular Genetics, 2007 - Oxford Univ Press The melanocortin-4 receptor (MC4R) gene pathogenic mutations are the most
prevalent forms of monogenic obesity, responsible for 2% of obesity cases, but
its role in common obesity is still elusive. We analyzed the contribution ... Cited by 27 - Related articles - BL Direct - All 6 versions
A Iida, S Saito, A Sekine, Y Kataoka, W … - Journal of Human Genetics, 2004 - Springer Abstract We previously published a series of detailed maps of single nucleotide
polymorphisms (SNPs) in the genomic regions of 209 gene loci encoding drug
metab- olizing enzymes, transporters, receptors, and other potential drug ... Cited by 13 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org F Stutzmann, K Tan, V Vatin, C Dina, B Jouret, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Of the MC4R nonsynonymous mutations found in obese subjects, 68%
resulted in a loss of function in vitro. They were found in 1.72% of obese
versus 0.15% of nonobesed subjects (P = 6.9 × 10 −10 ). Among the ... Cited by 10 - Related articles - All 5 versions
- ►pubget.com [PDF] RC Casper, EL Sullivan, L Tecott - Psychopharmacology, 2008 - Springer Abstract Background and rationale This review addresses the role animal models
play in contributing to our knowledge about the eating disorders anorexia
nervosa (AN) and bulimia nervosa (BN) and obesity. Objectives Explore the ... Cited by 8 - Related articles - All 7 versions
K Valli-Jaakola, JJ Palvimo, M Lipsanen- … - Horm Res, 2006 - content.karger.com Background/Aims: Mutations in melanocortin-4 receptor (MC4R) are the most common
genetic cause of human obesity. Mutations in MC4R promoter could also underlie
obesity, but have so far not been reported. Transcription factor nescient ... Cited by 7 - Related articles - BL Direct - All 8 versions
