- ►oxfordjournals.org MI McCarthy - Human Molecular Genetics, 2004 - Oxford Univ Press The rapid increase in the prevalence of type 2 diabetes (T2D) represents a major challenge for
health care delivery worldwide. Identification of genes influencing individual susceptibility to
disease offers a route to better understanding of the molecular mechanisms underlying ... Cited by 94 - Related articles - All 4 versions
- ►nih.gov N Tiffin, E Adie, F Turner, HG Brunner, MA van … - Nucleic acids …, 2006 - Oxford Univ Press Genome-wide experimental methods to identify disease genes, such as linkage analysis and
association studies, generate increasingly large candidate gene sets for which comprehensive
empirical analysis is impractical. Computational methods employ data from a variety of ... Cited by 48 - Related articles - BL Direct - All 20 versions
- ►endojournals.org SM Clee, AD Attie - Endocrine reviews, 2007 - Endocrine Soc Inbred mouse strains provide genetic diversity comparable to that of the human population. Like
humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse strains
differ in the response of their critical physiological functions, such as insulin sensitivity, ... Cited by 29 - Related articles - BL Direct - All 4 versions
JY Zhao, MM Xiong, W Huang, H Wang, J Zuo, GD … - Journal of Molecular …, 2005 - Springer J Mol Med (2005) 209:209–215 DOI 10.1007/s00109-004-0587-3 ... JY Zhao · MM Xiong ·
W. Huang · H. Wang · J. Zuo · GD Wu · Z. Chen · BQ Qiang · ML Zhang · JL Chen · W. Ding · WT
Yuan · HY Xu · L. Jin · YX Li · Q. Sun · QY Liu · E. Boerwinkle · FD Fang Cited by 26 - Related articles - All 3 versions
SK Das, SC Elbein - Cellscience, 2006 - pubmedcentral.nih.gov Type 2 Diabetes results from a complex physiologic process that includes the pancreatic beta
cells, peripheral glucose uptake in muscle, the secretion of multiple cytokines and hormone-like
molecules from adipocytes, hepatic glucose production, and likely the central nervous ... Cited by 25 - Related articles - All 3 versions
- ►ahajournals.org V Probst, S Le Scouarnec, A Legendre, V Jousseaume, … - Circulation, 2006 - Am Heart Assoc Methods and Results— We used the files of 2527 consecutive patients operated on for CAVS
in our institution between 1992 and 2002 to map the distribution of operated CAVS in the western
part of France. In a second step, we investigated clinically and genealogically the clusters ... Cited by 19 - Related articles - All 9 versions
- ►kuleuven.be [PDF] CC Elbers, NC Onland-Moret, L Franke, AG Niehoff, … - Trends in Endocrinology & …, 2007 - Elsevier Worldwide, the incidence of type 2 diabetes is rising rapidly, mainly because of the increase
in the incidence of obesity, which is an important risk factor for this condition. Both obesity and
type 2 diabetes are complex genetic traits but they also share some nongenetic risk ... Cited by 18 - Related articles - All 7 versions
MO Goodarzi, DM Lehman, KD Taylor, X Guo, J Cui, … - diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—A small number of susceptibility genes for human type 2 diabetes have been identified
by candidate gene analysis or positional cloning. Genes found to influence diabetes or related
traits in mice are likely to be susceptibility genes in humans. SorCS1 is the gene identified ... Cited by 14 - Related articles - BL Direct - All 12 versions
- ►jgenetgenomics.org [PDF] QY HUANG, MR CHENG, SL JI - Acta Genetica Sinica, 2006 - Elsevier Type 2 diabetes mellitus (T2DM) is a complex disease characterized by hyperglycemia, insulin
resistance, and impaired insulin secretion. T2DM is under strong genetic control. Identification
and characterization of genes involved in determining T2DM will contribute to a greater ... Cited by 10 - Related articles - All 3 versions
- ►diabetesjournals.org YS Aulchenko, J Pullen, WP Kloosterman, M … - Diabetes, 2007 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We investigated the region in a young genetically isolated
population by genotyping 34 single nucleotide polymorphisms (SNPs) in 78 case subjects and
101 control subjects. Two SNPs were selected and followed up in two cohorts. The first ... Cited by 9 - Related articles - BL Direct - All 3 versions
