- ►nih.gov E Seung, JP Mordes, AA Rossini, DL Greiner - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Allogeneic hematopoietic chimerism leading to central tolerance has significant
therapeutic potential. Realization of that potential has been impeded by the
need for myeloablative conditioning of the host and development of ... Cited by 61 - Related articles - BL Direct - All 9 versions
- ►nas.edu [PDF] JP Mordes, P Poussier, AR Rossini, EP … - Animal Models of Diabetes: Frontiers in Research - books.google.com 2 Animal Models of Diabetes BBDR Rats and Translational Modeling Fidelity 19
Immunological Perturbation and Diabetes Induction in Other Rat Strains 20
TLRLigation 20 Viral Infection 21 A Working Hypothesis of Autoimmune ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org T Pearson, TG Markees, DV Serreze, MA … - The Journal of Immunology, 2003 - Am Assoc Immnol Curing type 1 diabetes by islet transplantation requires overcoming both
allorejection and recurrent autoimmunity. This has been achieved with systemic
immunosuppression, but tolerance induction would be preferable. Most islet ... Cited by 30 - Related articles - BL Direct - All 7 versions
T Pearson, P Weiser, TG Markees, DV Serreze … - Diabetes, 2004 - Am Diabetes Assoc NOD mice develop type 1 autoimmune diabetes and exhibit genetically dominant
resistance to transplantation tolerance induction. These two phenotypes are
genetically separable. Costimulation blockade fails to prolong skin ... Cited by 16 - Related articles - BL Direct - All 6 versions
T Pearson, TG Markees, DV Serreze, MA … - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2003 - interscience.wiley.com Abstract: Recent advances in islet transplantation have enabled physicians to
cure type 1 autoimmune diabetes, but at the cost of lifelong immunosuppression
with its attendant side effects and long-term health risks. To eliminate ... Cited by 11 - Related articles - BL Direct - All 7 versions
E Seung, JP Mordes, DL Greiner, AA Rossini - Current Diabetes Reports, 2003 - Springer Introduction Type 1 diabetes Type 1 (“juvenile”) diabetes is caused by the
selective destruction of pancreatic β cells, leading to absolute defi- ciency
of insulin and hyperglycemia. The consensus view is that islet β -cell ... Cited by 8 - Related articles - BL Direct - All 4 versions
BC Beaudette-Zlatanova, B Whalen, D Zipris, … - American Journal of Transplantation, 2006 - interscience.wiley.com Costimulatory signals regulate T-cell activation. To investigate the role of
costimulation in autoimmunity and transplantation, we studied the BB rat model
of type 1 diabetes. Diabetes-prone BB (BBDP) rats spontaneously develop ... Cited by 8 - Related articles - BL Direct - All 5 versions
- ►nih.gov Y Li, L Ma, J Shen, AS Chong - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Alloreactive B cells can contribute to graft rejection. Anti-CD154 treatment
together with donor-specific transfusion (DST) results in the long-term survival
of MHC-mismatched mouse heart grafts and inhibition of alloantibody ... Cited by 7 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org EJ Gordon, LS Wicker, LB Peterson, DV … - Diabetes, 2005 - Am Diabetes Assoc Costimulation blockade induces prolonged rat islet and skin xenograft survival
in C57BL/6 mice. Nonobese diabetic (NOD) mice, which are used to model human
autoimmune diabetes, are resistant to costimulation blockade-induced ... Cited by 6 - Related articles - All 7 versions
- ►endojournals.org X Huang, DJ Moore, RJ Ketchum, CS … - Endocrine Reviews, 2008 - Endocrine Soc Although type 1 diabetes cannot be prevented or reversed, replacement of insulin
production by transplantation of the pancreas or pancreatic islets represents a
definitive solution. At present, transplantation can restore euglycemia, ... Cited by 5 - Related articles - All 4 versions
