KV Tarbell, S Yamazaki, K Olson, P Toy, RM … - Journal of Experimental …, 2004 - jem.rupress.org In the nonobese diabetic (NOD) mouse model of type 1 diabetes, the immune system recognizes
many autoantigens expressed in pancreatic islet ß cells. To silence autoimmunity, we used dendritic
cells (DCs) from NOD mice to expand CD25 + CD4 + suppressor T cells from BDC2.5 ... Cited by 349 - Related articles - BL Direct - All 9 versions
- ►tamu.edu [PDF] C King, A Ilic, K Koelsch, N Sarvetnick - Cell, 2004 - Elsevier During illness and stress, the immune system can suffer a considerable loss of T cells
(lymphopenia). The remaining T cells undergo vigorous compensatory expansion, known as
homeostatic proliferation, to reconstitute the immune system. Interestingly, human ... Cited by 295 - Related articles - All 14 versions
- ►diabetesjournals.org TM Brusko, CH Wasserfall, MJ Clare-Salzler, DA … - Diabetes, 2005 - Am Diabetes Assoc CD4 + CD25 + T-cells appear to play a crucial role in regulating the immune response.
Therefore, we evaluated the peripheral blood frequency and function of CD4 + CD25 + T-cells
in 70 type 1 diabetic patients and 37 healthy individuals. Interestingly, a positive ... Cited by 110 - Related articles - All 5 versions
- ►jimmunol.org JS Sutherland, GL Goldberg, MV Hammett, … - The Journal of …, 2005 - Am Assoc Immnol The thymus undergoes age-related atrophy, coincident with increased circulating sex steroids
from puberty. The impact of thymic atrophy is most profound in clinical conditions that cause a
severe loss in peripheral T cells with the ability to regenerate adequate numbers of naive ... Cited by 103 - Related articles - All 6 versions
- ►rupress.org KV Tarbell, L Petit, X Zuo, P Toy, X Luo, A … - Journal of Experimental …, 2007 - jem.rupress.org Most treatments that prevent autoimmune diabetes in nonobese diabetic (NOD) mice require
intervention at early pathogenic stages, when insulitis is first developing. We tested whether
dendritic cell (DC)–expanded, islet antigen–specific CD4 + CD25 + suppressor T cells ... Cited by 96 - Related articles - BL Direct - All 8 versions
RN Germain - Nature Medicine, 2004 - cmb1.auckland.ac.nz “Nature has provided, in the white corpuscles as you call them—in the phagocytes as we call
them—a natural means of devouring and destroying all disease germs. There is at bottom only
one genuinely scientific treatment for all diseases, and that is to stimulate the ... Cited by 71 - Related articles - BL Direct - All 6 versions
- ►highwire.org AM Marleau, N Sarvetnick - Journal of leukocyte biology, 2005 - jleuk.highwire.org The size of the peripheral T cell pool is remarkably stable throughout life, reflecting precise regulation
of cellular survival, proliferation, and apoptosis. Homeostatic proliferation refers to the process
by which T cells spontaneously proliferate in a lymphopenic host. The critical signals ... Cited by 44 - Related articles - BL Direct - All 6 versions
E Suri-Payer, B Fritzsching - Springer seminars in immunopathology, 2006 - Springer Page 1. REVIEW Regulatory T cells in experimental autoimmune disease Elisabeth
Suri-Payer & Benedikt Fritzsching Received: 23 March 2006 /Accepted: 17 May 2006 /
Published online: 13 July 2006 # Springer-Verlag 2006 ... Cited by 35 - Related articles - BL Direct - All 3 versions
P Alard, JN Manirarora, SA Parnell, JL Hudkins, SL … - Diabetes, 2006 - Am Diabetes Assoc Various defects in antigen-presenting cells (APCs) and T-cells, including regulatory cells, have
been associated with type 1 diabetes development in NOD mice. CD4 + CD25 + regulatory cells
play a crucial role in controlling various autoimmune diseases, and a deficiency in their ... Cited by 31 - Related articles - BL Direct - All 6 versions
SP Berzins, K Kyparissoudis, DG Pellicci, … - Immunology and cell …, 2004 - interscience.wiley.com Summary In the diabetes-prone NOD mouse, there is a proven association between a systemic
deficiency of NKT cells and the onset of type 1 diabetes. Numerous reports of similar defects
within the NKT cell compartment of human type 1 diabetes patients suggested NKT cell ... Cited by 30 - Related articles - BL Direct - All 5 versions
