Y Yang, P Santamaria - Diabetologia, 2003 - Springer Type 1 diabetes results from a genetically and immu- nologically complex autoimmune process
that is spe- cifically directed against the pancreatic beta cells. Non-obese diabetic mice spontaneously
develop a form of autoimmune diabetes closely resembling the disease in humans. This ... Cited by 21 - Related articles - BL Direct - All 4 versions
F Homo-Delarche - ILAR J, 2004 - dels.nas.edu Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which insulin-producing beta
cells of the pancre- atic islets of Langerhans are destroyed. The nonobese dia- betic (NOD) mouse
is one of the rare spontaneous models that enable the study of prediabetic pancreatic ... Cited by 14 - Related articles - View as HTML - BL Direct - All 2 versions
E Liu, H Moriyama, J Paronen, N Abiru, D Miao, L Yu, … - Journal of Autoimmunity, 2003 - Elsevier Introduction: Insulin peptide B:9-23 is a major autoantigen in type 1 diabetes that induces insulin
autoantibodies and prevents diabetes in the NOD. However, immunization with peptide without
adjuvant may be insufficient to reverse disease or induce long-term tolerance. ... Cited by 9 - Related articles - All 4 versions
- ►oxfordjournals.org G Rajagopalan, YC Kudva, L Chen, L Wen, … - International …, 2003 - Jpn Soc Immunol The major predisposing genetic component in type 1 diabetes (T1D) maps to the MHC locus
in both mice and humans. To better understand the HLA class II association with disease
pathogenesis, we bred mice expressing HLA-DQ8 and -DR3, either alone or in ... Cited by 9 - Related articles - All 4 versions
GS Eisenbarth, JM Jasinski - Endocrinology and metabolism clinics of North …, 2004 - Elsevier There are three major models of the time course of loss of islet β cells during the development
of type 1A (immune-mediated) diabetes mellitus [1]. The first chronic model [2] is supported by
progressive loss of β-cell mass (despite islet regeneration) in the nonobese diabetic ... Cited by 6 - Related articles - BL Direct - All 4 versions
AD Sanlioglu, TS Griffith, A Omer, E Dirice, R Sari, … - Journal of Cellular …, 2008 - trsgt.org Ahter Dilsad Sanlioglu,1 Thomas S. Griffith,2 Abdulkadir Omer,3 Ercument Dirice,1 Ramazan
Sari,4 Hasan Ali Altunbas,4 Mustafa Kemal Balci,4 and Salih Sanlioglu1* 1Human Gene Therapy
Unit and the Department of Medical Biology and Genetics, Akdeniz University, Faculty of ... Cited by 3 - Related articles - View as HTML - BL Direct - All 5 versions
- ►jimmunol.org G Chamberlain, M Wallberg, D Rainbow, K … - The Journal of …, 2006 - Am Assoc Immnol Identification of candidate genes and their immunological mechanisms that control autoaggressive
T cells in inflamed environments, may lead to novel therapies for autoimmune diseases, like
type 1 diabetes (T1D). In this study, we used transgenic NOD mice that constitutively ... Cited by 3 - Related articles - BL Direct - All 4 versions
G Rajagopalan, AK Mangalam, MM Sen, S Cheng, … - …, 2007 - informahealthcare.com Type 1 diabetes (T1D) is a polygenic autoimmune disease with a strong HLA association
particularly, HLA-DQ8. We investigated whether islet-specific expression of granulocyte/macrophage
colony-stimulating factor (Ins.GM-CSF) in Aß°.NOD.DQ8 mice (HLA-DQ8 transgenic mice ... Cited by 2 - Related articles - BL Direct - All 7 versions
G Rajagopalan, AK Mangalam, MM Sen, YC … - …, 2007 - informahealthcare.com The strong MHC class II association in human as well as murine Type 1 diabetes (T1D) suggests
a central role for CD4 + T cells in the disease pathogenesis. Nonetheless, CD8 + T cells also
play a role in the pathogenic process. We describe how CD4 + or CD8 + T cells can ... Cited by 2 - Related articles - BL Direct - All 5 versions