- ►endojournals.org I Kharroubi, L Ladriere, AK Cardozo, Z Dogusan, M … - Endocrinology, 2004 - Endocrine Soc Apoptosis is probably the main form of ß-cell death in both type 1 diabetes mellitus (T1DM) and
T2DM. In T1DM, cytokines contribute to ß-cell destruction through nuclear factor- B (NF- B)
activation. Previous studies suggested that in T2DM high glucose and free fatty acids ... Cited by 136 - Related articles - BL Direct - All 3 versions
AK Cardozo, F Ortis, J Storling, YM Feng, J Rasschaert, … - Diabetes, 2005 - Am Diabetes Assoc Cytokines and free radicals are mediators of β-cell death in type 1 diabetes. Under in vitro
conditions, interleukin-1β (IL-1β) + γ-interferon (IFN-γ) induce nitric oxide (NO) production and
apoptosis in rodent and human pancreatic β-cells. We have previously shown, by ... Cited by 102 - Related articles - All 8 versions
B Kutlu, AK Cardozo, MI Darville, M Kruhoffer … - DIABETES-NEW …, 2003 - Am Diabetes Assoc Locally released cytokines contribute to -cell dysfunc- tion and apoptosis in type 1 diabetes. In
vitro exposure of insulin-producing INS-1E cells to the cytokines inter- leukin (IL)-1 interferon
(IFN)- leads to a signifi- cant increase in apoptosis. To characterize the genetic networks ... Cited by 91 - Related articles - BL Direct - All 7 versions
- ►jbc.org M Cnop, L Ladriere, P Hekerman, F Ortis, AK … - Journal of Biological …, 2007 - ASBMB Free fatty acids cause pancreatic -cell apoptosis and may contribute to -cell loss in type 2 diabetes
via the induction of endoplasmic reticulum stress. Reductions in eukaryotic translation initiation
factor (eIF) 2 phosphorylation trigger -cell failure and diabetes. Salubrinal selectively ... Cited by 44 - Related articles - All 6 versions
- ►daegu.ac.kr [PDF] J Rasschaert, D Liu, B Kutlu, AK Cardozo, M Kruhøffer, … - Diabetologia, 2003 - Springer Aims/hypothesis. Viral infections and local production of IFN-γ might contribute to beta-cell
dysfunction/ death in Type 1 Diabetes. Double stranded RNA (dsRNA) accumulates in the cytosol
of viral-infected cells, and exposure of purified rat beta cells to dsRNA (tested in the form ... Cited by 41 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org N Welsh, M Cnop, I Kharroubi, M Bugliani, R Lupi, P … - Diabetes, 2005 - Am Diabetes Assoc Different degrees of β-cell failure and apoptosis are present in type 1 and type 2 diabetes. It has
been recently suggested that high glucose–induced β-cell apoptosis in type 2 diabetes shares
a final common pathway with type 1 diabetes, involving interleukin-1β (IL-1β) production ... Cited by 40 - Related articles - BL Direct - All 6 versions
DL Eizirik, B Kutlu, J Rasschaert, M … - ANNALS-NEW …, 2003 - interscience.wiley.com Abstract: The β cell fate following immune-mediated damage depends on an intricate pattern
of dozens of genes up- or downregulated in parallel and/or sequentially. We are utilizing microarray
analysis to clarify the pattern of gene expression in primary rat β cells exposed to the ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►endojournals.org F Ortis, AK Cardozo, D Crispim, J Storling, T … - Molecular …, 2006 - Endocrine Soc Cytokines, such as IL-1ß and TNF- , contribute to pancreatic ß-cell death in type 1 diabetes
mellitus. The transcription factor nuclear factor- B (NF- B) mediates cytokine-induced ß-cell
apoptosis. Paradoxically, NF- B has mostly antiapoptotic effects in other cell types. The ... Cited by 31 - Related articles - BL Direct - All 6 versions
H Elouil, AK Cardozo, DL Eizirik, JC Henquin, JC … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Hyperglycaemia and the pro- inflammatory cytokine IL-1β induce similar
alterations of beta cell gene expression, including up-regulation of c-Myc and haeme-oxygenase
1. These effects of hyperglycaemia may result from nuclear factor-kappa B (NFκB) ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell …, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss
in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the
molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in ... Cited by 23 - Related articles - All 5 versions
