- ►diabetesjournals.org DJ Drucker - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide
(GIP) exert important effects on β-cells to stimulate glucose-dependent insulin secretion. Both
peptides also regulate β-cell proliferation and cytoprotection. GLP-1, but not GIP, inhibits ... Cited by 284 - Related articles - All 13 versions
- ►endojournals.org DJ Drucker - Molecular Endocrinology, 2003 - Endocrine Soc Peptide hormones are secreted from endocrine cells and neurons and exert their actions through
activation of G protein-coupled receptors to regulate a diverse number of physiological systems
including control of energy homeostasis, gastrointestinal motility, neuroendocrine circuits, ... Cited by 228 - Related articles - BL Direct - All 8 versions
- ►endojournals.org PL Brubaker, DJ Drucker - Endocrinology, 2004 - Endocrine Soc Gut peptides exert diverse effects regulating satiety, gastrointestinal motility and acid
secretion, epithelial integrity, and both nutrient absorption and disposal. These actions are initiated
by activation of specific G protein-coupled receptors and may be mediated by direct or ... Cited by 217 - Related articles - BL Direct - All 7 versions
- ►endojournals.org L Farilla, A Bulotta, B Hirshberg, S Li Calzi, N Khoury, H … - Endocrinology, 2003 - Endocrine Soc The peptide hormone, glucagon-like peptide 1 (GLP-1), has been shown to increase
glucose-dependent insulin secretion, enhance insulin gene transcription, expand islet cell
mass, and inhibit ß-cell apoptosis in animal models of diabetes. The aim of the present ... Cited by 218 - Related articles - BL Direct - All 5 versions
LL Nielsen, AA Young, DG Parkes - Regulatory peptides, 2004 - Elsevier Exenatide (synthetic exendin-4), glucagon-like peptide-1 (GLP-1), and GLP-1 analogues have
actions with the potential to significantly improve glycemic control in patients with diabetes. Evidence
suggests that these agents use a combination of mechanisms which may include glucose- ... Cited by 185 - Related articles - All 7 versions
- ►physiology.org L Bouwens, I Rooman - Physiological reviews, 2005 - Am Physiological Soc Beta-cell mass regulation represents a critical issue for understanding diabetes, a disease characterized
by a near-absolute (type 1) or relative (type 2) deficiency in the number of pancreatic beta
cells. The number of islet beta cells present at birth is mainly generated by the ... Cited by 118 - Related articles - BL Direct - All 6 versions
- ►endojournals.org DJ Drucker - Endocrinology, 2003 - Endocrine Soc Studies of the natural history of type 2 diabetes inform us that a progressive decline in ß-cell
function is common in diabetic patients independent of the method of treatment (2). Hence, new
approaches are clearly needed that not only control metabolic abnormalities such as ... Cited by 102 - Related articles - BL Direct - All 4 versions
Q Wang, L Li, E Xu, V Wong, C Rhodes, PL Brubaker - Diabetologia, 2004 - Springer Aims/hypothesis. The incretin hormone glucagon-like peptide-1 augments islet cell mass in vivo
by increas- ing proliferation and decreasing apoptosis of the beta cells. However, the signalling
pathways that mediate these effects are mostly unknown. Using a clonal rat pancreatic ... Cited by 94 - Related articles - BL Direct - All 4 versions
- ►upenn.edu [PDF] M Teta, MM Rankin, SY Long, GM Stein, JA Kushner - Developmental cell, 2007 - Elsevier Cellular progenitors remain poorly characterized in many adult tissues, limited in part by the
lack of unbiased techniques to identify progenitors and their progeny. To address this fundamental
problem, we developed a novel DNA analog-based lineage-tracing technique to detect ... Cited by 89 - Related articles - All 12 versions
- ►nih.gov DJ Drucker - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The gastrointestinal tract has a crucial role in the control of energy homeostasis through its role
in the digestion, absorption, and assimilation of ingested nutrients. Furthermore, signals from
the gastrointestinal tract are important regulators of gut motility and satiety, both of which ... Cited by 87 - Related articles - BL Direct - All 11 versions
