- ►endojournals.org RL Hull, GT Westermark, P Westermark, SE … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these
deposits contain the unique amyloidogenic peptide islet amyloid polypeptide.
Autopsy studies in humans have demonstrated that islet amyloid is ... Cited by 118 - Related articles - BL Direct - All 6 versions
- ►psu.edu [PDF] RA Ritzel, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is characterized by a relative β-cell deficit as a result of
increased β-cell apoptosis and islet amyloid derived from the β-cell peptide
islet amyloid polypeptide (IAPP). Human IAPP (h-IAPP) but not mouse IAPP ... Cited by 73 - Related articles - BL Direct - All 9 versions
- ►yale.edu [PDF] JD Knight, AD Miranker - Journal of molecular biology, 2004 - Elsevier Islet amyloid polypeptide (IAPP) is a 37-residue hormone that forms cytotoxic
amyloid fibers in the endocrine pancreas of patients with type II diabetes
(NIDDM). A potential origin for cytotoxicity is disruption of lipid ... Cited by 62 - Related articles - All 6 versions
A Clark, MR Nilsson - Diabetologia, 2004 - Springer The role of islet amyloidosis in the onset and progres- sion of Type 2 diabetes
remains obscure. Islet amyloid polypeptide is a 37 amino-acid, beta-cell peptide
which is co-stored and co-released with insulin. Human islet amyloid ... Cited by 51 - Related articles - BL Direct - All 7 versions
MR Hayden, SC Tyagi, MM Kerklo, MR Nicolls - JOP. J Pancreas (Online), 2005 - joplink.net JOP. Journal of the Pancreas – http://www.joplink.net – Vol. 6, No. 4 –
July 2005. [ISSN 1590-8577] ... Type 2 Diabetes Mellitus as a Conformational
Disease ... Melvin R Hayden1, Suresh C Tyagi2, Michelle M Kerklo3, Mark R ... Cited by 43 - Related articles - View as HTML - All 5 versions
LA Leiter - Diabet Med, 2005 - interscience.wiley.com Type 2 diabetes is caused by progressively increasing insulin resistance coupled
with deteriorating β-cell function, and there is a growing body of evidence to
suggest that both of these defects precede hyperglycaemia by many years. ... Cited by 36 - Related articles - BL Direct - All 6 versions
RL Hull, K Kodama, KM Utzschneider, DB … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Increased dietary fat intake is associated with
obesity and insulin resistance, but studies have shown that the subsequent
increase in insulin release is not appropriate for this obesity-induced ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►shouxi.net RL Hull, ZP Shen, MR Watts, K Kodama, DB … - Diabetes, 2005 - Am Diabetes Assoc Islet amyloid deposition in type 2 diabetes is associated with reduced β-cell
mass. Therefore, interventions aimed at reducing islet amyloid formation may
help preserve β-cell mass in type 2 diabetes. Rosiglitazone and metformin ... Cited by 23 - Related articles - All 6 versions
R Muff, W Born, TA Lutz, JA Fischer - Peptides, 2004 - Elsevier The hormone calcitonin (CT) of thyroid C-cell origin, the neuropeptides α- and
β-calcitonin gene-related peptide (CGRP), the widely expressed hormone and
tissue factor adrenomedullin (AM), and amylin (AMY) that is co-produced ... Cited by 22 - Related articles - All 4 versions
AV Matveyenko, PC Butler - ILAR JOURNAL, 2006 - dels.nas.edu Blood glucose concentrations are maintained by insulin se- creted from ß-cells
located in the islets of Langerhans. There are ∼2000 ß-cells per islet, and
∼one million islets of Langerhans scattered throughout the pancreas. The ... Cited by 15 - Related articles - View as HTML - BL Direct - All 2 versions
