- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in
the islets of Langerhans involving activation of apoptosis and necrosis and the
production of proinflammatory molecules that negatively influence islet ... Cited by 72 - Related articles - BL Direct - All 4 versions
X Li, H Chen, PN Epstein - Journal of Biological Chemistry, 2004 - ASBMB Islet transplantation is a promising therapy for Type 1 diabetes, but many
attempts have failed due to early graft hypoxia or immune rejection, which
generate reactive oxygen species (ROS). In the current study, we determined ... Cited by 66 - Related articles - BL Direct - All 5 versions
H Kaneto, N Katakami, D Kawamori, T … - Antioxidants & redox signaling, 2007 - liebertonline.com F AILURE OF PANCREATIC cells is the common characteris- tic of type 1 and type 2
diabetes. Type 1 diabetes melli- tus is induced by destruction of pancreatic
cells, which is mediated by an autoimmune mechanism and the consequent ... Cited by 47 - Related articles - BL Direct - All 4 versions
- ►endojournals.org D Scheuner, RJ Kaufman - Endocrine Reviews, 2008 - Endocrine Soc The endoplasmic reticulum (ER) is the entry site into the secretory pathway for
newly synthesized proteins destined for the cell surface or released into the
extracellular milieu. The study of protein folding and trafficking within ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►ualberta.ca [PDF] AN Balamurugan, R Bottino, N Giannoukakis … - Pancreas, 2006 - journals.lww.com Abstract: Pancreatic islet cell transplantation is an attractive treatment of
type 1 diabetes (T1D). The success enhanced by the Edmonton protocol has
fostered phenomenal progress in the field of clinical islet transplantation ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org MJ Perone, S Bertera, ZS Tawadrous, WJ … - The Journal of Immunology, 2006 - Am Assoc Immnol Type 1 diabetes (T1D) is a disease caused by the destruction of the cells of the
pancreas by activated T cells. Dendritic cells (DC) are the APC that initiate
the T cell response that triggers T1D. However, DC also participate in T ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►shouxi.net TB Mysore, TA Shinkel, J Collins, EJ Salvaris … - Diabetes, 2005 - Am Diabetes Assoc Primary nonfunction of transplanted islets results in part from their
sensitivity to reactive oxygen species (ROS) generated during the isolation and
transplantation process. Our aim was to examine whether coexpression of ... Cited by 27 - Related articles - All 5 versions
- ►diabetesjournals.org Z Wang, T Zhu, KK Rehman, S Bertera, J … - Diabetes, 2006 - Am Diabetes Assoc Diabetes is a disease of epidemic proportions and is on the rise worldwide. Gene
therapy has been actively pursued but limited by technical hurdles and profound
inefficiency of direct gene transfer to the pancreas in vivo. Here, we show ... Cited by 26 - Related articles - BL Direct - All 6 versions
PPM Rood, R Bottino, AN Balamurugan, C … - Transplantation, 2007 - journals.lww.com Transplantation. Wolters Kluwer Health Logo. All Issues. ... Cited by 22 - Related articles - BL Direct - All 3 versions
AN Balamurugan, J He, F Guo, DB Stolz, S … - American Journal of Transplantation, 2005 - interscience.wiley.com The isolation process exposes human pancreatic islets to exogenous isolation
enzymes. Exposure to these enzymes, as a result of intraductal injection in the
pancreas or simple contact of islets with enzyme components, causes ... Cited by 20 - Related articles - BL Direct - All 4 versions
