C Li, C Buettger, J Kwagh, A Matter, Y Daikhin, IB … - Journal of Biological …, 2004 - ASBMB Children with hypoglycemia due to recessive loss of function mutations of the β-cell ATP-sensitive
potassium (K ATP ) channel can develop hypoglycemia in response to protein feeding. We hypothesized
that amino acids might stimulate insulin secretion by unknown mechanisms, because the ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org A Tarasov, J Dusonchet, F Ashcroft - Diabetes, 2004 - Am Diabetes Assoc Closure of ATP-sensitive K + channels (K ATP channels) is a key step in glucose-stimulated
insulin secretion. The precise mechanism(s) by which glucose metabolism regulates K ATP channel
activity, however, remains controversial. It is widely believed that the principal ... Cited by 48 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org IR Sweet, DL Cook, E DeJulio, AR Wallen, G Khalil, J … - Diabetes, 2004 - Am Diabetes Assoc ATP and ADP levels are critical regulators of glucose-stimulated insulin secretion. In many aerobic
cell types, the phosphorylation potential (ATP/ADP/P i ) is controlled by sensing mechanisms
inherent in mitochondrial metabolism that feed back and induce compensatory changes ... Cited by 37 - Related articles - BL Direct - All 5 versions
J Grimsby, FM Matschinsky, JF Grippo - Glucokinase and Glycemic … - books.google.com Fig. 3. Close-up of GKA binding site showing amino acid residues making direct interactions
with a GKA. Mutations in V62, M210 and M235 cause the MODY-2 pheno- type whereas
V455M, A456V and Y214A mutations increase the catalytic activity of GK [3-5]. The ... Cited by 21 - Related articles - BL Direct - All 3 versions
- ►physiology.org LE Fridlyand, L Ma, LH Philipson - American Journal of …, 2005 - Am Physiological Soc Glucose metabolism stimulates insulin secretion in pancreatic -cells. A consequence of metabolism
is an increase in the ratio of ATP to ADP ([ATP]/[ADP]) that contributes to depolarization of the
plasma membrane via inhibition of ATP-sensitive K + (K ATP ) channels. The subsequent ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►physiology.org NM Doliba, SL Wehrli, MZ Vatamaniuk, W … - American Journal of …, 2007 - Am Physiological Soc Fuel stimulation of insulin secretion from pancreatic -cells is thought to be mediated by metabolic
coupling factors that are generated by energized mitochondria, including protons, adenine
nucleotides, and perhaps certain amino acids (AA), as for instance aspartate, glutamate, ... Cited by 1 - Related articles - BL Direct - All 5 versions
L Brennan, C Hewage, JP Malthouse, NH … - FEBS …, 2006 - interscience.wiley.com Prolonged exposure of pancreatic beta cells to the sulfonylureas glibencamide and tolbutamide
induces subsequent desensitization to the actions of these drugs. The precise mechanisms underlying
this desensitization remain unknown, prompting the present study, which investigated the ... Cited by 1 - Related articles - BL Direct - All 4 versions
AP de Deux - Diabetes, 2004 - Am Diabetes Assoc Closure of ATP-sensitive K + channels (KATP channels) is a key step in glucose-stimulated insulin
secretion. The precise mechanism(s) by which glucose metabolism regulates KATP channel
activity, however, remains con- troversial. It is widely believed that the principal deter- ... Related articles - All 2 versions